Boston Children's Hospital, Brookline, MA, USA.
University of Denver, CO, USA.
J Atten Disord. 2022 Sep;26(11):1422-1436. doi: 10.1177/10870547221075842. Epub 2022 Feb 1.
In the last decade, there has been an increase in research that aims to parse heterogeneity in attention deficit hyperactivity disorder (ADHD). The current study tests heritability of latent class neuropsychological subtypes.
Latent class analysis was used to derive subtypes in a sample of school-age twins ( = 2,564) enriched for elevated ADHD symptoms.
Five neuropsychological profiles replicated across twin 1 and twin 2 datasets. Latent class membership was heritable overall, but heritability varied by profile and was lower than heritability of ADHD status. Variability in neuropsychological performance across domains was the strongest predictor of elevated ADHD symptoms. Neuropsychological profiles showed distinct associations with age, psychiatric symptoms and reading ability.
Neuropsychological profiles are associated with unique neurocognitive presentations, but are not strong candidate endophenotypes for ADHD diagnosis.
在过去的十年中，旨在解析注意力缺陷多动障碍（ADHD）异质性的研究有所增加。本研究测试潜在类别神经心理学亚型的遗传性。
使用潜在类别分析从一个有 ADHD 症状升高的学龄双胞胎样本（= 2564）中得出亚型。
在双胞胎 1 和双胞胎 2 数据集上均复制了五个神经心理学特征。潜在类别成员身份总体上具有遗传性，但遗传率因特征而异，且低于 ADHD 状态的遗传率。跨领域神经心理表现的可变性是 ADHD 症状升高的最强预测因素。神经心理学特征与年龄、精神症状和阅读能力有明显的关联。
神经心理学特征与独特的神经认知表现相关，但不是 ADHD 诊断的强候选内表型。
