儿童注意缺陷多动障碍神经相关因素的纵向稳定性：事件相关电位和脑电图的初步研究。
Longitudinal Stability of Neural Correlates of Pediatric Attention Deficit Hyperactivity Disorder: A Pilot Study of Event Related Potentials and Electroencephalography.
机构信息
Boston Children's Hospital, MA, USA.
Harvard Medical School, Boston, MA, USA.
出版信息
J Atten Disord. 2024 Feb;28(4):493-511. doi: 10.1177/10870547231214983. Epub 2023 Dec 28.
OBJECTIVE
Stability and developmental effects of electroencephalography (EEG) and event related potential (ERP) correlates of ADHD are understudied. This pilot study examined stability and developmental changes in ERP and EEG metrics of interest.
METHODS
Thirty-seven 7 to 11-year-old children with ADHD and 15 typically developing (TD) children completed EEG twice, 11 to 36 months apart. A series of mixed effects linear models were run to examine stability and developmental effects of EEG and ERP metrics.
RESULTS
Stability and developmental effects of EEG and ERP correlates of ADHD varied considerably across metrics. P3 amplitude was stable over time and showed diverging developmental trajectories across groups. Developmental differences were apparent in error related ERPs and resting aperiodic exponent. Theta-beta ratio was stable over time among all children.
CONCLUSIONS
Developmental trajectories of EEG and ERP correlates of ADHD are candidate diagnostic markers. Replication with larger samples is needed.
目的
注意力缺陷多动障碍（ADHD）的脑电图（EEG）和事件相关电位（ERP）相关性的稳定性和发展影响研究不足。本初步研究旨在检测感兴趣的 ERP 和 EEG 指标的稳定性和发展变化。
方法
37 名 7 至 11 岁的 ADHD 儿童和 15 名正常发育（TD）儿童相隔 11 至 36 个月进行两次 EEG 检查。运行了一系列混合效应线性模型，以检查 EEG 和 ERP 指标的稳定性和发展影响。
结果
ADHD 的 EEG 和 ERP 相关性的稳定性和发展影响在各项指标上差异很大。P3 振幅随时间稳定，且在组间表现出不同的发展轨迹。错误相关 ERP 和静息非周期性指数表现出明显的发展差异。所有儿童的θ-β 比随时间稳定。
结论
ADHD 的 EEG 和 ERP 相关性的发展轨迹是候选的诊断标志物。需要更大的样本进行复制。
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