托珠单抗治疗甲型肝炎诱发的巨噬细胞活化综合征合并全身型幼年特发性关节炎：一例报告
Management of Hepatitis A-induced Macrophage Activation Syndrome With Anakinra in Systemic Juvenile Idiopathic Arthritis: A Case Report.
作者信息
AlNouwaiser Deena N, AlMutairi Sajdi S, AlRowailey Abdullah S
机构信息
Department of Pediatrics, King Saud University Medical City, Riyadh, SAU.
出版信息
Cureus. 2022 Jan 19;14(1):e21430. doi: 10.7759/cureus.21430. eCollection 2022 Jan.
Abstract
Macrophage activation syndrome (MAS) is a severe and life-threatening complication of rheumatic diseases in childhood. It is most associated with systemic juvenile idiopathic arthritis (sJIA). We present the case of a nine-year-old boy diagnosed with sJIA for six years who developed MAS triggered by hepatitis A. He was managed with anakinra and corticosteroids. Some of the clinical features of MAS occur late in the disease course, so clinicians should keep a high index of suspicion to initiate treatment early. This case highlights that anakinra and corticosteroid use in treating MAS is effective and has a good safety profile for pediatric patients.
摘要
巨噬细胞活化综合征（MAS）是儿童风湿性疾病的一种严重且危及生命的并发症。它与全身型幼年特发性关节炎（sJIA）最为相关。我们报告一例9岁男孩，诊断为sJIA 6年，因甲型肝炎引发MAS。他接受了阿那白滞素和皮质类固醇治疗。MAS的一些临床特征在病程后期才出现，因此临床医生应保持高度怀疑指数以便早期启动治疗。该病例突出显示，阿那白滞素和皮质类固醇用于治疗MAS对儿科患者有效且安全性良好。
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