Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Newborn Research, Royal Women's Hospital, Melbourne, Victoria, Australia.
Dev Med Child Neurol. 2022 Jul;64(7):855-862. doi: 10.1111/dmcn.15167. Epub 2022 Feb 1.
To determine the relationship between early motor repertoire and 2-year neurodevelopment in infants born extremely preterm (<28 weeks' gestation) or extremely-low-birthweight (ELBW) (<1000g).
This was a geographical prospective cohort of 139 infants born extremely preterm/ELBW (mean gestational age 26.7 weeks, standard deviation [SD] 2.0, 68/139 [49%] male), with parent-recorded videos suitable for scoring the General Movements Assessment (GMA). Motor repertoire was assessed using the Motor Optimality Score-Revised (MOS-R), with and without the fidgety movement subsection, and the GMA alone at 12 to 13 weeks corrected age and 14 to 15 weeks corrected age. At 2 years corrected age, impaired development was defined as Bayley Scales of Infant and Toddler Development, Third Edition motor and cognitive development scores 1SD or less relative to controls born at term; paediatricians diagnosed cerebral palsy (CP).
Greater MOS-R scores at 14 to 15 weeks corrected age were associated with lower odds of CP (odds ratio [OR] per 1-point increase=0.83, 95% confidence interval [CI]=0.71-0.99), and motor (OR=0.93, 95% CI=0.87-0.99), or cognitive impairment (OR=0.94, 95% CI=0.88-0.99). Absent/abnormal GMA at 14 to 15 weeks was associated with CP and motor delay. There was little evidence that MOS-R scores at 12 to 13 weeks were associated with neurodevelopmental outcomes at 2 years.
Poorer MOS-R scores and absent/abnormal GMA, scored from parent-recorded videos at 14 to 15 weeks gestational age, are associated with CP and developmental impairment in 2-year-old infants born extremely preterm/ELBW.
确定极早产（<28 周妊娠）或极低出生体重儿（<1000g）婴儿早期运动模式与 2 岁神经发育的关系。
这是一项地理性前瞻性队列研究，纳入了 139 名极早产/极低出生体重儿（平均胎龄 26.7 周，标准差为 2.0，68/139 [49%]为男性），他们的父母录制了适合进行全身运动评估（GMA）评分的视频。运动模式采用运动优化评分修订版（MOS-R）进行评估，包括和不包括烦躁运动亚节，以及单独使用 GMA，分别在 12 至 13 周校正年龄和 14 至 15 周校正年龄进行评估。在 2 岁校正年龄时，贝利婴幼儿发育量表第三版运动和认知发育评分低于对照组 1 个标准差定义为发育障碍；儿科医生诊断为脑瘫（CP）。
14 至 15 周校正年龄时 MOS-R 评分较高与 CP（每增加 1 分的优势比[OR]=0.83，95%置信区间[CI]=0.71-0.99）、运动（OR=0.93，95% CI=0.87-0.99）或认知障碍（OR=0.94，95% CI=0.88-0.99）的可能性降低相关。14 至 15 周时 GMA 缺失/异常与 CP 和运动迟缓相关。MOS-R 评分在 12 至 13 周时与 2 岁时神经发育结局的相关性很小。
14 至 15 周时 MOS-R 评分较差和 GMA 缺失/异常，由父母记录的视频评分，与极早产/极低出生体重儿 2 岁时 CP 和发育障碍相关。
