Koroliuk I P, Bykhovskaia A M, Bykhovskaia E Iu
Med Radiol (Mosk). 1986 Jan;31(1):22-6.
The time course of the concentration of immunoreactive insulin (IRI) and C-peptide in the plasma and erythrocytes and the blood sugar level in GTT per os were investigated. Altogether 73 healthy persons and 52 patients with a severe form of insulin-dependent diabetes mellitus were examined. To define the time course of changes in the concentration of the above values a rate gradient determined as a difference of changed concentration rate for the 1st and 2nd hour after load for each examined person, was proposed. The most significant differences in the healthy persons and patients were noted in the plasma IRI basal level and blood sugar basal levels. The rate gradient defined most completely the time course of carbohydrate metabolism. The gradients C-peptide had maximum difference in healthy persons and patients. The hormone and blood sugar levels characterized the condition of the examined persons, and rate gradients were indicative of the state of the blood sugar regulation system.
研究了口服葡萄糖耐量试验（GTT）中血浆和红细胞中免疫反应性胰岛素（IRI）和C肽浓度的时间进程以及血糖水平。共检查了73名健康人和52名重度胰岛素依赖型糖尿病患者。为了确定上述值浓度变化的时间进程，提出了一个速率梯度，该梯度定义为每个受检者负荷后第1小时和第2小时浓度变化率的差值。健康人和患者之间最显著的差异在于血浆IRI基础水平和血糖基础水平。速率梯度最完整地定义了碳水化合物代谢的时间进程。C肽梯度在健康人和患者之间差异最大。激素和血糖水平表征了受检者的状况，而速率梯度则表明了血糖调节系统的状态。
