Methylation of DNA guanine via the 1-carbon pool in dimethylnitrosamine-treated rats.
作者信息
Barrows L R
出版信息
Mutat Res. 1986 Jan;173(1):73-9. doi: 10.1016/0165-7992(86)90014-x.
PMID:3510380
Abstract
Treatment of rats with radioactive methionine and nonradioactive dimethylnitrosamine resulted in the formation of radioactive 7-methylguanine in rat-liver DNA. By comparing the specific activity of administered [14C-Me]-dimethylnitrosamine to the specific activity of isolated 7-methylguanine it was determined that following 20 mg/kg dimethylnitrosamine DNA methylation via the 1-carbon pool may account for up to 30% of the total 7-methylguanine formed.
摘要
相似文献
1
Methylation of DNA guanine via the 1-carbon pool in dimethylnitrosamine-treated rats.
Mutat Res. 1986 Jan;173(1):73-9. doi: 10.1016/0165-7992(86)90014-x.
2
3
Methylation of DNA guanine during the course of induction of liver cancer in hamsters by hydrazine or dimethylnitrosamine.在仓鼠中用肼或二甲基亚硝胺诱导肝癌过程中DNA鸟嘌呤的甲基化。
Carcinogenesis. 1987 Mar;8(3):439-44. doi: 10.1093/carcin/8.3.439.
4
Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus.N-亚硝基乙甲胺的β-氘代导致大鼠肝脏至食管的DNA甲基化发生转移。
Carcinogenesis. 1991 Apr;12(4):545-9. doi: 10.1093/carcin/12.4.545.
5
6
DNA methylation in rat liver by daminozide, 1,1-dimethylhydrazine, and dimethylnitrosamine.丁酰肼、1,1-二甲基肼和二甲基亚硝胺对大鼠肝脏DNA甲基化的影响
Fundam Appl Toxicol. 1988 Nov;11(4):723-30. doi: 10.1016/0272-0590(88)90135-2.
7
Stability and capacity of dimethylnitrosamine-induced O6-methylguanine repair system in rat liver.二甲基亚硝胺诱导的大鼠肝脏O6-甲基鸟嘌呤修复系统的稳定性和容量
Cancer Res. 1983 Dec;43(12 Pt 1):5808-14.
8
Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.二甲基亚硝胺的代谢以及分离的大鼠肝细胞随后从DNA中去除O6-甲基鸟嘌呤的过程。
Chem Biol Interact. 1981 Jan;33(2-3):229-38. doi: 10.1016/0009-2797(81)90043-0.
9
In vivo replication of carcinogen-modified rat liver DNA: increased susceptibility of O6-methylguanine compared to N-7-methylguanine in replicated DNA to S1-nuclease.致癌物修饰的大鼠肝脏DNA的体内复制：与N-7-甲基鸟嘌呤相比，复制DNA中的O6-甲基鸟嘌呤对S1核酸酶的敏感性增加。
Biochem Biophys Res Commun. 1980 Jul 31;95(2):816-21. doi: 10.1016/0006-291x(80)90860-8.
10
[DNA alkylation during endogenous synthesis of N-nitrosodimethylamine].
Eksp Onkol. 1987;9(1):11-4.
Zotero 插件