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Methylation of DNA guanine via the 1-carbon pool in dimethylnitrosamine-treated rats.

作者信息

Barrows L R

出版信息

Mutat Res. 1986 Jan;173(1):73-9. doi: 10.1016/0165-7992(86)90014-x.

DOI:10.1016/0165-7992(86)90014-x
PMID:3510380
Abstract

Treatment of rats with radioactive methionine and nonradioactive dimethylnitrosamine resulted in the formation of radioactive 7-methylguanine in rat-liver DNA. By comparing the specific activity of administered [14C-Me]-dimethylnitrosamine to the specific activity of isolated 7-methylguanine it was determined that following 20 mg/kg dimethylnitrosamine DNA methylation via the 1-carbon pool may account for up to 30% of the total 7-methylguanine formed.

摘要

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Methylation of DNA guanine via the 1-carbon pool in dimethylnitrosamine-treated rats.
Mutat Res. 1986 Jan;173(1):73-9. doi: 10.1016/0165-7992(86)90014-x.
2
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