Oechslin M, Thiel G, Landmann J, Gloor B
Transplantation. 1986 Jan;41(1):60-2. doi: 10.1097/00007890-198601000-00012.
Retinal cotton-wool patches, not previously observed in bone marrow recipients, have been reported in three patients who received Sandimmun (cyclosporine) as prophylaxis for graft-versus-host-disease after bone marrow transplantation. These patients all had acute lymphoblastic leukemia and had received, in addition to the standard conditioning regimen, central nervous system irradiation before transplantation. We were thus prompted to examine 55 renal transplant recipients (15 of them prospectively) who were receiving cyclosporine for evidence of similar fundal changes. No cotton-wool patches were found in any of the renal transplant recipients.
视网膜棉絮斑此前在骨髓移植受者中未被观察到，据报道，三名接受山地明（环孢素）预防骨髓移植后移植物抗宿主病的患者出现了这种情况。这些患者均患有急性淋巴细胞白血病，除了标准预处理方案外，移植前还接受了中枢神经系统照射。因此，我们对55名接受环孢素治疗的肾移植受者（其中15名是前瞻性研究对象）进行了检查，以寻找类似眼底改变的证据。在任何肾移植受者中均未发现棉絮斑。
