miRNA-30c-2-3p 通过靶向 STRIP2 抑制胃癌细胞的恶性进展。
MicroRNA-30c-2-3p targets STRIP2 to suppress malignant progression of gastric cancer cells.
机构信息
Department of General Surgery, First People's Hospital of Tonglu, Tonglu 311500, China.
出版信息
J Biochem. 2022 Mar 31;171(4):451-457. doi: 10.1093/jb/mvac006.
MicroRNA plays a crucial part in genesis and development of gastric cancer (GC). We uncovered that microRNA-30c-2-3p was down-regulated in GC tissue and cell lines. Suppression of microRNA-30c-2-3p promoted progression of GC cells in vitro. STRIP2 was confirmed as a target for microRNA-30c-2-3p. MicroRNA-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of STRIP2 partially restored the anticancer effect of microRNA-30c-2-3p. Taken together, these findings suggested that microRNA-30c-2-3p acted as a candidate tumour suppressor in GC by directly targeting STRIP2. Therefore, microRNA-30c-2-3p can be used as a towardly GC therapeutic target.
微小 RNA 在胃癌（GC）的发生和发展中起着至关重要的作用。我们发现微小 RNA-30c-2-3p 在 GC 组织和细胞系中下调。抑制微小 RNA-30c-2-3p 促进了 GC 细胞在体外的进展。STRIP2 被确认为微小 RNA-30c-2-3p 的靶标。微小 RNA-30c-2-3p 的过表达显著抑制了细胞的恶性行为，而 STRIP2 的重新引入部分恢复了微小 RNA-30c-2-3p 的抗癌作用。总之，这些发现表明微小 RNA-30c-2-3p 通过直接靶向 STRIP2 作为 GC 的候选肿瘤抑制因子发挥作用。因此，微小 RNA-30c-2-3p 可作为一种有前途的 GC 治疗靶点。
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