Onda M, Toba M, Andoh T, Shirota A
Circ Shock. 1986;18(1):11-9.
To determine the effects of low-dose heparin on the reticuloendothelial system in shock, rats were subjected to intraperitoneal administration of E coli endotoxin. Alterations such as degeneration and necrosis of the Kupffer cells and sinusoidal endothelial cells were observed in the livers of the non-heparin-treated animals 4 hours after the administration of the endotoxin. These changes progressed with time. Kupffer cells in the heparin-treated rats appeared undisturbed up to 8-12 hours post endotoxin challenge. Phagocytosis of cell remained slight in the heparin-treated rats. The mortality rate of the heparin-treated group was 10% with LD50 endotoxin (7.6 mg/kg). The mortality rate of the untreated control group 24 hours after administration was 50%. However, when endotoxin was administered in a dosage of 30 mg/kg (MLD), the mortality rate of the heparin-treated rats was 60%--10% greater than that of controls (P less than 0.05).
为了确定小剂量肝素对休克时网状内皮系统的影响，对大鼠腹腔注射大肠杆菌内毒素。在内毒素注射4小时后，未用肝素治疗的动物肝脏中观察到诸如库普弗细胞和窦状内皮细胞变性和坏死等改变。这些变化随时间进展。在内毒素攻击后长达8 - 12小时，用肝素治疗的大鼠的库普弗细胞似乎未受影响。用肝素治疗的大鼠中细胞吞噬作用仍然轻微。用肝素治疗的组在给予半数致死量内毒素（7.6毫克/千克）时死亡率为10%。给药24小时后未治疗的对照组死亡率为50%。然而，当以30毫克/千克（最小致死量）的剂量给予内毒素时，用肝素治疗的大鼠的死亡率比对照组高60% - 10%（P小于0.05）。
