McClendon C E, Leff R D, Clark E B
Drug Intell Clin Pharm. 1986 Jan;20(1):20-3. doi: 10.1177/106002808602000103.
Postpericardiotomy syndrome, a frequent complication of open-heart surgery, is characterized by fever, chest pain, and pericardial and pleural effusions. These signs may develop 1 to 12 weeks after intracardiac surgery in approximately 30 percent of patients. Although the etiology of the syndrome is unknown, evidence points to a viral and/or autoimmune cause. Postpericardiotomy syndrome is diagnosed after excluding other conditions such as endocarditis and pneumonia. In many cases, the syndrome is self-limiting and occurs only once, but in other cases the symptoms have recurred as many as eight times. When the symptoms recur, management is more difficult because optimal pharmacologic treatment is not known. Antiinflammatory agents, such as salicylates and steroids, represent the drugs most commonly used. Although analgesics with codeine or oxycodone are important for the patients' symptomatic relief, early recognition of the syndrome is the key to limiting the discomfort and possible complications associated with this condition.
心脏切开术后综合征是心脏直视手术常见的并发症，其特征为发热、胸痛以及心包和胸腔积液。这些症状可能在心脏手术后1至12周出现，约30%的患者会出现。尽管该综合征的病因不明，但有证据表明是由病毒和/或自身免疫引起的。心脏切开术后综合征在排除其他疾病如心内膜炎和肺炎后得以诊断。在许多情况下，该综合征是自限性的，且仅发作一次，但在其他情况下，症状会复发多达八次。当症状复发时，治疗会更加困难，因为尚不清楚最佳的药物治疗方法。抗炎药，如水杨酸盐和类固醇，是最常用的药物。尽管含可待因或羟考酮的镇痛药对缓解患者症状很重要，但早期识别该综合征是减轻与该病症相关的不适和可能并发症的关键。
