Gabriel S M, Berglund L A, Simpkins J W
Endocrinology. 1986 Feb;118(2):558-61. doi: 10.1210/endo-118-2-558.
Studies were undertaken to evaluate the influence of endogenous opioid peptides (EOP) on the LH hypersecretion induced in ovariectomized rats by estradiol benzoate (EB) or EB plus progesterone (EBP). Naloxone (0.1-15.0 mg/kg) was injected before (1200 h) and during (1400 and 1530 h) the LH surge induced by EBP treatment and during the LH surge after EB treatment (1600 h). The opiate antagonist readily stimulated LH secretion before the LH surge in EBP-treated rats at 1200 h and during the LH surge in EB-treated rats at 1600 h, but was much less effective during the LH hypersecretion induced by EBP treatment at 1400 and 1530 h. This decline in the LH secretory response to naloxone during the EBP-induced LH surge was not due to changes in the response of pituitary to LHRH. These studies indicate that during the period of LH hypersecretion induced by the sequential administration of EB plus P, the influence of EOP neuronal systems on LH secretion is diminished. Thus, EOP neurons may play a role in the timing and magnitude of the LH surge in EBP-treated rats.
开展了多项研究，以评估内源性阿片肽（EOP）对苯甲酸雌二醇（EB）或EB加孕酮（EBP）诱导的去卵巢大鼠促黄体生成素（LH）分泌过多的影响。在EBP处理诱导的LH峰之前（1200 h）、期间（1400和1530 h）以及EB处理后的LH峰期间（1600 h）注射纳洛酮（0.1 - 15.0 mg/kg）。在1200 h接受EBP处理的大鼠LH峰前以及1600 h接受EB处理的大鼠LH峰期间，阿片类拮抗剂容易刺激LH分泌，但在1400和1530 h EBP处理诱导的LH分泌过多期间效果要差得多。在EBP诱导的LH峰期间，LH对纳洛酮分泌反应的这种下降并非由于垂体对促性腺激素释放激素（LHRH）反应的改变。这些研究表明，在依次给予EB加P诱导LH分泌过多的期间，EOP神经元系统对LH分泌的影响减弱。因此，EOP神经元可能在EBP处理的大鼠LH峰的时间和幅度方面发挥作用。
