关于环孢素治疗的昼夜节律、近一周节律和近一年节律优化需求的更多内容。
More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy.
作者信息
Liu T, Cavallini M, Halberg F, Cornelissen G, Field J, Sutherland D E
出版信息
Experientia. 1986 Jan 15;42(1):20-2. doi: 10.1007/BF01975877.
PMID:3510897
Abstract
Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.
摘要
对胰腺同种异体移植大鼠进行环孢素时间疗法发现，除了同等日剂量存在昼夜阶段依赖性外，每日剂量以约7天的周期变化还能进一步改善移植功能，首次最高剂量在术后第3天或第5天给予。
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