时间对肾移植排斥反应的可能影响。
Possible effect of time on renal allograft rejection.
作者信息
Knapp M S, Cove-Smith J R, Dugdale R, Mackenzie N, Pownall R
出版信息
Br Med J. 1979 Jan 13;1(6156):75-7. doi: 10.1136/bmj.1.6156.75.
Abstract
The change in plasma creatinine concentrations from decreasing values after successful renal transplantation to increasing values after the onset of rejection occurs as a sudden event. Twenty-two such episodes in 16 renal allograft recipients were studied by extrapolating sequential measurements of plasma creatinine concentrations to see when the change occurred. Seventeen of the episodes occurred between 2300 and 1100 and the rest at other times. This difference was significant. The results suggest that rejection is more common at night and apparently has a circadian rhythm, being likely to first influence creatinine clearance at around 0600.
摘要
肾移植成功后血浆肌酐浓度从下降转为排斥反应开始后的上升是一个突然发生的变化。通过外推血浆肌酐浓度的连续测量值来研究16例肾移植受者中的22次此类情况，以确定变化发生的时间。其中17次情况发生在23:00至11:00之间，其余发生在其他时间。这种差异具有显著性。结果表明，排斥反应在夜间更为常见，且显然具有昼夜节律，可能在06:00左右首先影响肌酐清除率。
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