2-甲硫基-N6-异戊烯基腺苷缺乏对大肠杆菌中肽基-tRNA释放的影响。
Effect of a 2-methylthio-N6-isopentenyladenosine deficiency on peptidyl-tRNA release in Escherichia coli.
作者信息
Petrullo L A, Elseviers D
出版信息
J Bacteriol. 1986 Feb;165(2):608-11. doi: 10.1128/jb.165.2.608-611.1986.
Abstract
We examined the effect of miaA, a mutation conferring a deficiency in 2-methylthio-N6-isopentenyladenosine in tRNA, on patterns of peptidyl-tRNA accumulation in Escherichia coli strains deficient in peptidyl-tRNA hydrolase activity. A specific reduction in peptidyl-tRNA accumulation was seen for tRNAs which normally contain the 2-methylthio-N6-isopentenyladenosine modification. These results provide new evidence in support of the ribosome editor model, which links peptidyl-tRNA release to mistranslation events.
摘要
我们研究了miaA（一种导致tRNA中2-甲硫基-N6-异戊烯基腺苷缺乏的突变）对肽基-tRNA水解酶活性缺陷的大肠杆菌菌株中肽基-tRNA积累模式的影响。对于通常含有2-甲硫基-N6-异戊烯基腺苷修饰的tRNA，观察到肽基-tRNA积累有特定减少。这些结果为核糖体编辑模型提供了新证据，该模型将肽基-tRNA释放与错误翻译事件联系起来。
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2
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3
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4
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6
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