Sotiropoulos Christos, Sakka Eftichia, Theocharis Georgios J, Thomopoulos Konstantinos C
Gastroenterology, University General Hospital of Patra, Patra, GRC.
Internal Medicine, General Hospital of Patra "St Andrew", Patra, GRC.
Cureus. 2021 Dec 27;13(12):e20749. doi: 10.7759/cureus.20749. eCollection 2021 Dec.
Sweet syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. The exact pathogenesis of Sweet syndrome is unclear, however, autoimmune and inflammatory conditions including inflammatory bowel disease have been linked as underlying etiologies. Since its description, in 1964, there have been published less than fifty reports of Crohn's-associated Sweet syndrome. We report a 43-year-old male patient with a medical history of Crohn's disease who subsequently developed Sweet syndrome. Two years after the diagnosis of Crohn's disease the patient was administered a combo therapy with Infliximab and Azathioprine followed by deep remission. A few months later the patient manifested with skin lesions with histopathological findings suggestive of Sweet syndrome. Sweet syndrome, although rare, may occur as an extra-intestinal manifestation of Crohn's disease. This report illustrates the need for a thorough investigation of patients with Crohn's disease presenting with skin lesions. We hope it will add to the current literature and help understand this rare phenomenon in order to achieve a proper diagnosis.
斯威特综合征，又称急性发热性嗜中性皮病，是一种罕见的炎症性疾病。斯威特综合征的确切发病机制尚不清楚，然而，自身免疫性和炎症性疾病，包括炎症性肠病，已被认为是潜在病因。自1964年首次描述以来，关于克罗恩病相关斯威特综合征的报道不足50例。我们报告一例43岁男性患者，有克罗恩病病史，随后患上斯威特综合征。在诊断克罗恩病两年后，患者接受了英夫利昔单抗和硫唑嘌呤联合治疗，随后病情深度缓解。几个月后，患者出现皮肤病变，组织病理学检查结果提示为斯威特综合征。斯威特综合征虽然罕见，但可能作为克罗恩病的肠外表现出现。本报告表明，对于出现皮肤病变的克罗恩病患者，需要进行全面检查。我们希望它能丰富现有文献，并有助于理解这一罕见现象，以便做出正确诊断。
