Chaudhari Kaustubh S, Tiwari Rakesh R, Chaudhari Saurabh S, Joshi Swati V, Singh Harish B
Department of Internal Medicine, Dr. V.M. Government Medical College, Solapur, IND.
Department of Samhita Siddhanta, Smt. K.G. Mittal Punarvasu Ayurvedic College, Mumbai, IND.
Cureus. 2021 Dec 28;13(12):e20775. doi: 10.7759/cureus.20775. eCollection 2021 Dec.
Non-motor symptoms of Parkinson's disease (PD), such as insomnia and restless legs syndrome (RLS), tend to worsen and become refractory as neurodegeneration progresses. We report the case of a 72-year-old female with a six-year history of PD and two-and-half-year history of insomnia and refractory RLS. We added a neuroprotective agent, , to the existing treatment regimen for her insomnia. Besides the partial remission of her insomnia and motor symptoms of PD, there was a complete reversal of the RLS symptoms. has been shown to improve PD symptoms by preventing oxidative damage of the nigrostriatal dopaminergic neurons and improving dopamine levels in the midbrain and corpus striatum. Our case provides the first-time evidence where added for insomnia caused a complete remission of refractory RLS, possibly due to its anti-apoptotic and pro-dopaminergic actions. could prove beneficial in cases where the disease advances but further addition of dopamine agonists for refractory RLS is not possible due to the risk of dopamine augmentation.
帕金森病（PD）的非运动症状，如失眠和不宁腿综合征（RLS），往往会随着神经退行性变的进展而恶化并变得难治。我们报告了一例72岁女性患者，有6年帕金森病病史，2年半失眠和难治性不宁腿综合征病史。我们在她现有的失眠治疗方案中添加了一种神经保护剂。除了她的失眠和帕金森病运动症状部分缓解外，不宁腿综合征症状完全逆转。已证明通过防止黑质纹状体多巴胺能神经元的氧化损伤和提高中脑及纹状体中的多巴胺水平来改善帕金森病症状。我们的病例首次提供了证据，即添加用于治疗失眠导致难治性不宁腿综合征完全缓解，可能是由于其抗凋亡和促多巴胺能作用。在疾病进展但由于多巴胺增加风险而无法进一步添加多巴胺激动剂治疗难治性不宁腿综合征的情况下，可能证明是有益的。
