Sertl K, Takemura T, Tschachler E, Ferrans V J, Kaliner M A, Shevach E M
J Exp Med. 1986 Feb 1;163(2):436-51. doi: 10.1084/jem.163.2.436.
In this study, we identified a population of dendritic cells (DC) that exists throughout human and mouse pulmonary tissues, including the trachea, bronchi, alveoli, and visceral pleura. In human tissue, these DC were shown to be positive for HLA-DR and T200 antigens. In the mouse, the DC expressed not only Ia and the T200 antigen, but also Fc-IgG and C3bi receptors. Unlike alveolar macrophages, the DC were negative for nonspecific esterase staining and shared ultrastructural similarities with the DC described by Steinman (1), and with Langerhans' cells, even though they did not contain Birbeck granules. We were able to demonstrate that mouse pulmonary DC function in antigen presentation, as observed with the other DC. Thus, the respiratory tract contains DC that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.
在本研究中，我们鉴定出一类树突状细胞（DC）群体，其存在于整个人类和小鼠的肺组织中，包括气管、支气管、肺泡和脏层胸膜。在人体组织中，这些DC显示对HLA - DR和T200抗原呈阳性。在小鼠中，DC不仅表达Ia和T200抗原，还表达Fc - IgG和C3bi受体。与肺泡巨噬细胞不同，DC对非特异性酯酶染色呈阴性，并且与Steinman（1）描述的DC以及朗格汉斯细胞具有超微结构上的相似性，尽管它们不含伯贝克颗粒。我们能够证明，正如在其他DC中所观察到的那样，小鼠肺DC具有抗原呈递功能。因此，呼吸道含有能够发挥抗原呈递功能的DC，并且可能在肺部免疫反应中起重要作用。
