Martines Gennaro, Tomasicchio Giovanni, Picciariello Arcangelo, Dibra Rigers, Trigiante Giuseppe, Lantone Giuliano, Altomare Donato Francesco
Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", Piazza Giulio Cesare, 11, Bari, Puglia, Italy.
Open Med (Wars). 2022 Jan 19;17(1):197-204. doi: 10.1515/med-2022-0426. eCollection 2022.
A dreaded complication of laparoscopic sleeve gastrectomy (LSG) is suture leak. The study aimed to assess the efficacy of the nebulized comonomer Glubran 2 (-butyl-cyanoacrylate + metacrylosysolfolane) applied to the LSG staple line.
A propensity-matched comparison analysis was conducted in 125 patients undergoing LSG between 2017 and 2019. Groups included those treated with Glubran (group 1, = 70) and those without Glubran treatment (group 2, = 55).
There were differences in the mean body mass index (44.4 vs 43 kg/m; < 0.05) between the groups. There was a non-significant increase in the operative time for group 1 compared with group 2 (97 ± 8 vs 93.8 ± 10.7 min; = 0.07), with a greater amount of estimated blood loss (94.5 mL vs 87.8; < 0.01). There were more severe complications in group 2 over group 1 cases (8 vs 0%; < 0.05), although postoperative bleeding did not differ between the two groups (1.4 vs 5.4%). There were no postoperative leaks in group 1 patients, but there were two leaks in group 2 cases with an increased length of hospital stay in patients with a leak.
Glubran LSG support may reduce leak risk without increasing operating time.
腹腔镜袖状胃切除术（LSG）令人担忧的并发症是缝合口漏。本研究旨在评估雾化共聚单体Glubran 2（-丁基-氰基丙烯酸酯+甲基丙烯酸溶纤剂）应用于LSG吻合钉线的疗效。
对2017年至2019年间接受LSG的125例患者进行倾向匹配比较分析。分组包括接受Glubran治疗的患者（第1组，n = 70）和未接受Glubran治疗的患者（第2组，n = 55）。
两组间平均体重指数存在差异（44.4 vs 43 kg/m²；P < 0.05）。与第2组相比，第1组手术时间有非显著性增加（97 ± 8 vs 93.8 ± 10.7分钟；P = 0.07），估计失血量更多（94.5 mL vs 87.8 mL；P < 0.01）。第2组的严重并发症比第1组更多（8% vs 0%；P < 0.05），尽管两组术后出血情况无差异（1.4% vs 5.4%）。第1组患者无术后漏，而第2组有2例漏，漏患者的住院时间延长。
Glubran对LSG的支持可能降低漏的风险而不增加手术时间。
