Department of Anaesthesia and Pain Management, Royal North Shore Hospital, St Leonards, Australia.
Anaesth Intensive Care. 2022 Mar;50(1-2):68-80. doi: 10.1177/0310057X211070003. Epub 2022 Feb 3.
Misuse of prescription opioids forced an inevitable response from authorities to intervene with consequences felt by all.In the Australian community one person will die for approximately every 3600 adults prescribed opioids, while in the hospital setting a postoperative patient managed primarily with opioids, as opposed to epidural analgesia, has an additional risk of death as high as between one in 56 to 477.Opioids maintain a valid role in acute pain management when use is reasoned and with full awareness of the harms and how they are to be avoided, such as in those at risk of ongoing use, the opioid naïve, and when opioid-induced ventilatory impairment may occur.Clinicians managing acute pain can focus on assessing pain versus nociception, strategically apply antinociceptive medications and neural blockade when indicated, assess pain with an emphasis on the degree of bothersomeness and functional impairment and, finally, optimise the use of framing and placebo-enhancing communication to minimise reliance on medications.
处方类阿片的滥用迫使当局采取干预措施,由此产生的后果影响到所有人。在澳大利亚,每约 3600 名开处阿片类药物的成年人中就有 1 人死亡,而在医院环境中,与硬膜外镇痛相比,主要使用阿片类药物管理的术后患者的死亡风险高达 1/56 至 1/477。当使用合理且充分了解危害及其避免方法时,阿片类药物在急性疼痛管理中仍具有有效作用,例如在有持续使用风险、阿片类药物无经验以及可能发生阿片类药物引起的通气障碍的患者中。管理急性疼痛的临床医生可以专注于评估疼痛与伤害感受,在有指征时策略性地应用镇痛药物和神经阻滞,重点评估疼痛的困扰程度和功能障碍程度,最后,优化框架和安慰剂增强沟通的使用,以最大程度减少对药物的依赖。