Department of Anesthesiology, School of Medicine, University of Colorado, Aurora, CO, USA; Department of Pharmacology, School of Medicine, University of Colorado, Aurora, CO, USA.
Br J Anaesth. 2022 Mar;128(3):411-413. doi: 10.1016/j.bja.2022.01.002. Epub 2022 Feb 1.
Despite substantial advocacy for the scientific community to focus on sex-specific differences in biology, the role of sex hormones remains inadequately studied in the field of anaesthesia-induced developmental neurotoxicity. A recent study by Yang and colleagues published in this journal addresses the importance of studying sex hormones during critical stages of brain development. The authors demonstrate that exogenous testosterone administered to immature mice pups around the time of sevoflurane exposure increased brain levels of testosterone, attenuated tau phosphorylation, inhibited glycogen synthase kinase-3β activation and its interaction/binding with tau, reversed sevoflurane-induced decreases in neuronal activation, and attenuated cognitive impairments. Their well-designed experiments suggest an important role that testosterone plays in balancing several important pathways crucial for neuronal protection and normal function of neuronal circuits in the male mammalian brain.
尽管有大量的倡导呼吁科学界关注生物学中的性别特异性差异，但在麻醉诱导的发育神经毒性领域，性激素的作用仍未得到充分研究。最近，Yang 及其同事在该杂志上发表的一项研究强调了在大脑发育关键阶段研究性激素的重要性。作者表明，在七氟醚暴露时给幼鼠注射外源性睾酮会增加大脑中的睾酮水平，减轻 tau 磷酸化，抑制糖原合成酶激酶-3β的激活及其与 tau 的相互作用/结合，逆转七氟醚诱导的神经元激活减少，并减轻认知障碍。他们精心设计的实验表明，睾酮在平衡几个重要途径方面发挥着重要作用，这些途径对雄性哺乳动物大脑中神经元的保护和神经元回路的正常功能至关重要。
