Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA.
Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA.
Br J Anaesth. 2022 Apr;128(4):602-605. doi: 10.1016/j.bja.2021.12.040. Epub 2022 Feb 1.
Anaesthesia exposure early in life potentially impairs neurobehavioural development. A recent study in the Journal investigated the possibility that progesterone mitigates anaesthesia-induced developmental neurotoxicity in neonatal rats exposed to sevoflurane. The novel findings show that the steroid hormone progesterone protects against development of behavioural alterations caused by sevoflurane. The protective mechanism is proposed to relate to anti-inflammatory properties of progesterone, which brings up important questions regarding the role of inflammation in mediating the neurobehavioural alterations in anaesthesia-induced developmental neurotoxicity. We discuss this mechanism and encourage new research that may clarify the underlying mechanisms of progesterone-induced protection and extend these findings into a translational model.
生命早期接触麻醉可能会损害神经行为发育。最近发表在《杂志》上的一项研究探讨了孕激素是否可以减轻新生大鼠接触七氟醚麻醉诱导的发育性神经毒性。新的研究结果表明，甾体激素孕激素可以预防七氟醚引起的行为改变。提出的保护机制与孕激素的抗炎特性有关，这就提出了关于炎症在介导麻醉诱导的发育性神经毒性的神经行为改变中的作用的重要问题。我们讨论了这一机制，并鼓励开展新的研究，以阐明孕激素诱导保护的潜在机制，并将这些发现扩展到转化模型中。
