一种古老的发育诱导：在孢子形成和卵子发生过程中诱导产生的热休克蛋白。

An ancient developmental induction: heat-shock proteins induced in sporulation and oogenesis.

作者信息

Kurtz S, Rossi J, Petko L, Lindquist S

出版信息

Science. 1986 Mar 7;231(4742):1154-7. doi: 10.1126/science.3511530.

Abstract

Every eukaryotic and prokaryotic organism tested to date synthesizes a small number of heat-shock proteins in response to heat and other forms of stress. A particular pattern of heat-shock gene expression was observed during ascospore development in Saccharomyces: heat-shock proteins hsp26 and hsp84 were strongly induced nor inducible by heat shock. Instead, two proteins related to hsp70 were induced. A strikingly similar pattern of expression occurs during oogenesis in Drosophila, suggesting that it may be one of the earliest developmental pathways to evolve in eukaryotic cells.

摘要

迄今为止，每一种接受测试的真核生物和原核生物都会在受热及其他形式的应激时合成少量热休克蛋白。在酿酒酵母的子囊孢子发育过程中，观察到了一种特定的热休克基因表达模式：热休克蛋白hsp26和hsp84在受热时既不会被强烈诱导，也不会被诱导。相反，两种与hsp70相关的蛋白质被诱导产生。在果蝇的卵子发生过程中也出现了惊人相似的表达模式，这表明它可能是真核细胞中最早进化出来的发育途径之一。