Chen Mai-Lin, Wei Yi-Yuan, Li Xiao-Ting, Qi Li-Ping, Sun Ying-Shi
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.
Transl Cancer Res. 2021 Jun;10(6):2841-2848. doi: 10.21037/tcr-20-3479.
To explore the value of the quantitative parameters of low-dose computed tomography (CT) perfusion in the diagnosis of lung cancers of different pathological types.
Eighty-five patients with lung cancer confirmed by pathology underwent enhanced spectral CT imaging with a General Electric (GE) Revolution Xtream CT scanner, including 7 patients with lung squamous cell carcinoma, 8 patients with small cell carcinoma, 67 patients with lung adenocarcinoma, and 3 patients with other pathologies. The low-dose CT perfusion parameters [blood flow (BF), blood volume (BV), time of arrival (IRF TO), maximum slope of increase (MSI), mean transit time (MTT), positive enhancement integral (PEI), time to peak (TTP) and time to maximum (Tmax)] were calculated and compared among the first three groups. One-way analysis of variance (ANOVA) or the Kruskal-Wallis test was used to compare the quantitative parameters among the three groups, and the Bonferroni method was used to correct for multiple comparisons.
Among the quantitative parameters, MSI was significantly different among the three lung cancers (adenocarcinoma squamous cell carcinoma small cell carcinoma: 11.37±8.74 2.35±0.88 1.40±0.26, respectively; P=0.016). The MSI of lung adenocarcinoma was lower than that of non-adenocarcinoma (P=0.001), and the MSI of small cell carcinoma was lower than that of non-small cell carcinoma (P=0.014). There were no significant differences in the other parameters among these three groups (P>0.05).
Low-dose CT perfusion parameters may have a certain value in classifying the pathological type of lung cancer.
探讨低剂量计算机断层扫描（CT）灌注定量参数在不同病理类型肺癌诊断中的价值。
85例经病理确诊的肺癌患者使用通用电气（GE）Revolution Xtream CT扫描仪进行增强光谱CT成像，其中肺鳞状细胞癌7例，小细胞癌8例，肺腺癌67例，其他病理类型3例。计算前三组的低剂量CT灌注参数[血流量（BF）、血容量（BV）、达峰时间（IRF TO）、最大上升斜率（MSI）、平均通过时间（MTT）、阳性增强积分（PEI）、峰值时间（TTP）和最大时间（Tmax）]并进行比较。采用单因素方差分析（ANOVA）或Kruskal-Wallis检验比较三组间的定量参数，采用Bonferroni法进行多重比较校正。
在定量参数中，三种肺癌之间的MSI有显著差异（腺癌、鳞状细胞癌、小细胞癌的MSI分别为11.37±8.74、2.35±0.88、1.40±0.26；P = 0.016）。肺腺癌的MSI低于非腺癌（P = 0.001），小细胞癌的MSI低于非小细胞癌（P = 0.014）。三组间其他参数无显著差异（P>0.05）。
低剂量CT灌注参数在肺癌病理类型分类中可能具有一定价值。
