Barron W M, Mujais S K, Zinaman M, Bravo E L, Lindheimer M D
Am J Obstet Gynecol. 1986 Jan;154(1):80-4. doi: 10.1016/0002-9378(86)90397-2.
The dynamic response of the sympathoadrenal system was evaluated during and after pregnancy in 13 healthy women with a protocol that compared cardiovascular parameters and plasma catecholamine levels during the basal state, after postural maneuvers, and following isometric exercise. Plasma epinephrine and norepinephrine levels were similar during and after gestation when the women rested on their sides, but heart rate was greater in pregnancy. Ten minutes of supine recumbency produced minimal changes, but attenuation of the anticipated increases in heart rate and plasma norepinephrine levels during standing and isometric exercise were observed during pregnancy. In contrast, alterations in plasma epinephrine appeared unaffected by gestation. Plasma renin activity and aldosterone levels were, as expected, greater during pregnancy; however, increments in response to upright posture were similar in pregnant and postpartum women. To the extent that circulating catecholamines may be considered indices of sympathoadrenal function, these data suggest that normal pregnancy alters cardiovascular and sympathetic nervous system responses to physiologic stimuli.
采用一项方案，对13名健康女性在孕期及产后交感肾上腺系统的动态反应进行了评估，该方案比较了基础状态、体位改变后以及等长运动后心血管参数和血浆儿茶酚胺水平。当这些女性侧卧休息时，孕期和产后血浆肾上腺素和去甲肾上腺素水平相似，但孕期心率更高。仰卧10分钟产生的变化极小，但在孕期观察到站立和等长运动期间预期的心率和血浆去甲肾上腺素水平升高减弱。相比之下，血浆肾上腺素的变化似乎不受妊娠影响。正如预期的那样，孕期血浆肾素活性和醛固酮水平更高；然而，妊娠和产后女性对直立姿势的反应增量相似。就循环儿茶酚胺可被视为交感肾上腺功能指标而言，这些数据表明正常妊娠会改变心血管和交感神经系统对生理刺激的反应。
