Guezennec C Y, Defer G, Cazorla G, Sabathier C, Lhoste F
Eur J Appl Physiol Occup Physiol. 1986;54(6):632-7. doi: 10.1007/BF00943352.
The purpose of this study was to determine the response of plasma renin activity (PRA), plasma aldosterone concentration (PAC) and catecholamines to two graded exercises differing by posture. Seven male subjects (19-25 years) performed successively a running rest on a treadmill and a swimming test in a 50-m swimming pool. Each exercise was increased in severity in 5-min steps with intervals of 1 min. Oxygen consumption, heart rate and blood lactate, measured every 5 min, showed a similar progression in energy expenditure until exhaustion, but there was a shorter time to exhaustion in the last step of the running test. PRA, PAC and catecholamines were increased after both types of exercise. The PRA increase was higher after the running test (20.9 ng AngI X ml-1 X h-1) than after swimming (8.66 ng AngI X ml-1 X h-1). The PAC increase was slightly greater after running (123 pg X ml-1) than swimming (102 pg X ml-1), buth the difference was not significant. Plasma catecholamine was higher after the swimming test. These results suggest that the volume shift induced by the supine position and water pressure during swimming decreased the PRA response. The association after swimming compared to running of a decreased PRA and an enhanced catecholamine response rule out a strict dependence of renin release under the effect of plasma catecholamines and is evidence of the major role of neural pathways for renin secretion during physical exercise.
本研究的目的是确定血浆肾素活性（PRA）、血浆醛固酮浓度（PAC）和儿茶酚胺对两种因姿势不同而分级的运动的反应。七名男性受试者（19 - 25岁）先后在跑步机上进行跑步休息以及在50米游泳池中进行游泳测试。每次运动强度以5分钟的步长递增，间隔1分钟。每5分钟测量一次耗氧量、心率和血乳酸，结果显示在运动至疲惫之前能量消耗有相似的进展，但跑步测试的最后一步达到疲惫的时间更短。两种运动后PRA、PAC和儿茶酚胺均升高。跑步测试后PRA的升高幅度（20.9 ng AngI X ml-1 X h-1）高于游泳后（8.66 ng AngI X ml-1 X h-1）。跑步后PAC的升高幅度（123 pg X ml-1）略大于游泳后（102 pg X ml-1），但差异不显著。游泳测试后血浆儿茶酚胺水平更高。这些结果表明，游泳过程中仰卧姿势和水压引起的容量转移降低了PRA反应。与跑步相比，游泳后PRA降低而儿茶酚胺反应增强，这排除了血浆儿茶酚胺作用下肾素释放的严格依赖性，证明了神经通路在体育锻炼期间肾素分泌中起主要作用。
