间皮素的表达水平可提示恶性胸膜间皮瘤的预后。
Level of mesothelin expression can indicate the prognosis of malignant pleural mesothelioma.
作者信息
Feng Feifei, Zhang Huanan, Zhang Ying, Wang Hui
机构信息
Department of Respiratory Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
出版信息
Transl Cancer Res. 2020 Dec;9(12):7479-7485. doi: 10.21037/tcr-19-2027.
BACKGROUND
Malignant pleural mesothelioma (MPM) is a fatal, treatment-resistant tumor. The median survival of MPM is 9-12 months and its early prognostic markers remains uncertain. The objective of this study was to determine that the level of mesothelin expression can be as a predictor of prognosis in MPM patients.
METHODS
Level of mesothelin expression was detected in 38 MPM tissue specimens by immunohistochemistry analysis. The relationship of MPM prognosis and mesothelin expression was evaluated by univariate and multivariate Cox regression, Kaplan-Meier survival curves.
RESULTS
High level of mesothelin expression was significantly associated with non-epithelioid type of MPM and smoking. Meanwhile, higher level of mesothelin expression indicated a shorter total survival.
CONCLUSIONS
The present study suggested that mesothelin is a dependent prognostic factor in MPM patients and might be a novel potential target for immunotherapy in MPM.
背景
恶性胸膜间皮瘤（MPM）是一种致命的、对治疗耐药的肿瘤。MPM的中位生存期为9至12个月，其早期预后标志物仍不确定。本研究的目的是确定间皮素表达水平能否作为MPM患者预后的预测指标。
方法
通过免疫组织化学分析检测38例MPM组织标本中间皮素的表达水平。采用单因素和多因素Cox回归、Kaplan-Meier生存曲线评估MPM预后与间皮素表达的关系。
结果
间皮素高表达与非上皮样型MPM和吸烟显著相关。同时，间皮素表达水平越高，总生存期越短。
结论
本研究表明间皮素是MPM患者的独立预后因素，可能是MPM免疫治疗的一个新的潜在靶点。
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