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老年女性低风险早期乳腺癌的辅助放疗:来自随机试验的证据

Adjuvant radiotherapy for low-risk early breast cancer in elderly women: evidence from randomized trials.

作者信息

Burgos-Burgos Javier, Pinar-Sedeño Beatriz, García-Cabrera Laura, Rodríguez-Ibarria Nieves, Cabezón-Pons Auxiliadora, Lloret-Sáenz-Bravo Marta, Vicente-Rubio Elena, Vega-Benítez Víctor, Travieso-Aja María, Lara Pedro C

机构信息

Oncology Department, San Roque University Hospital, Las Palmas de Gran Canaria, Spain.

Radiation Oncology Department, Dr. Negrin University Hospital, Las Palmas de Gran Canaria, Spain.

出版信息

Transl Cancer Res. 2020 Jan;9(Suppl 1):S207-S216. doi: 10.21037/tcr.2019.08.38.

DOI:10.21037/tcr.2019.08.38
PMID:35117964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8799074/
Abstract

Breast cancer is the most common cancer pathology in women in the Western world. The median age at diagnosis is 60 years and in the coming decades it is estimated that the number of elderly women affected reaches an important percentage. This aging of the cancer population, associated with its inherent comorbidities and aggravated by the lack of consensus about the most appropriate treatment, make it difficult to administer an effective postoperative treatment in elderly women with a low-risk profile. An exhaustive geriatric evaluation is a sine qua non condition to opt for a specific type of treatment. To date, several options are available such as endocrine therapy (ET) alone, moderate/high hypofractionation and various accelerated partial breast irradiation (APBI) techniques. In this article, we provide information about each of them.

摘要

乳腺癌是西方世界女性中最常见的癌症病理类型。诊断时的中位年龄为60岁,预计在未来几十年中,受影响的老年女性数量将达到相当大的比例。癌症患者群体的老龄化,加上其固有的合并症,以及由于对最合适的治疗方法缺乏共识而加剧的情况,使得对低风险特征的老年女性进行有效的术后治疗变得困难。详尽的老年医学评估是选择特定治疗类型的必要条件。迄今为止,有几种选择,如单独的内分泌治疗(ET)、中等/高度低分割放疗以及各种加速部分乳腺照射(APBI)技术。在本文中,我们提供了关于它们每一种的信息。

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本文引用的文献

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The American Brachytherapy Society consensus statement for accelerated partial-breast irradiation.美国近距离放射治疗学会关于加速部分乳腺照射的共识声明。
Brachytherapy. 2018 Jan-Feb;17(1):154-170. doi: 10.1016/j.brachy.2017.09.004. Epub 2017 Oct 23.
2
NCCN Guidelines Insights: Older Adult Oncology, Version 2.2016.NCCN 指南解读:老年肿瘤学,第 2.2016 版。
J Natl Compr Canc Netw. 2016 Nov;14(11):1357-1370. doi: 10.6004/jnccn.2016.0146.
3
Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial.早期乳腺癌术中放疗后的美容效果及与乳房相关的生活质量结局:TARGIT-A试验的一项子研究
Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):55-64. doi: 10.1016/j.ijrobp.2016.04.024. Epub 2016 Apr 23.
4
Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT.乳腺癌靶向术中放疗的环境和社会效益:来自英国TARGIT-A试验中心及两家提供TARGIT术中放疗的英国国民健康服务体系(NHS)医院的数据。
BMJ Open. 2016 May 9;6(5):e010703. doi: 10.1136/bmjopen-2015-010703.
5
Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.与英国FAST-Forward试验中采用的标准3周方案相比,全乳放疗1周方案相关的急性皮肤毒性。
Radiother Oncol. 2016 Jul;120(1):114-8. doi: 10.1016/j.radonc.2016.02.027. Epub 2016 Apr 1.
6
5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial.5 年结果:保乳手术后采用单纯间质内多导管近距离放疗与全乳放疗加局部推量治疗低危型女性乳腺浸润性癌和原位癌的对比:一项随机、3 期、非劣效性试验。
Lancet. 2016 Jan 16;387(10015):229-38. doi: 10.1016/S0140-6736(15)00471-7. Epub 2015 Oct 19.
7
Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer.傲慢、偏见还是科学:对乳腺癌术中靶向放疗TARGIT-A试验结果的态度
Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):491-7. doi: 10.1016/j.ijrobp.2015.03.022. Epub 2015 Apr 8.
8
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Oncologist. 2015 Apr;20(4):379-85. doi: 10.1634/theoncologist.2014-0247. Epub 2015 Mar 12.
9
Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.65 岁或以上早期乳腺癌女性中保乳手术联合或不联合放疗(PRIME II):一项随机对照试验。
Lancet Oncol. 2015 Mar;16(3):266-73. doi: 10.1016/S1470-2045(14)71221-5. Epub 2015 Jan 28.
10
Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial.调强放射治疗加速部分乳腺照射与全乳照射的比较:一项3期随机对照试验的5年生存分析
Eur J Cancer. 2015 Mar;51(4):451-463. doi: 10.1016/j.ejca.2014.12.013. Epub 2015 Jan 17.