单剂量和多剂量口服阿莫西林在鹅体内的药代动力学评价。

Single and multiple oral amoxicillin treatment in geese: a pharmacokinetic evaluation.

Department of Veterinary Medicine, University of Sassari, Sassari, Italy.

Department of Pharmacology, Toxicology and Environmental Protection, University of Life Sciences, Lublin, Poland.

Br Poult Sci. 2022 Aug;63(4):493-498. doi: 10.1080/00071668.2022.2036699. Epub 2022 Feb 23.

Abstract

Although amoxicillin has broad-spectrum antibiotic activity and is extensively used in poultry, its use has never been investigated in geese. This study aimed to evaluate the pharmacokinetics of amoxicillin after a single and multiple oral doses in geese.2. A total of 20 geese were enrolled in this study and randomly pooled in two groups ( = 10). In group I, animals were treated with a single oral 20 mg/kg dose of amoxicillin, while geese in group II were administered multiple doses (20 mg/kg/day for 4 d). Concentrations of amoxicillin in plasma were analysed using a validated HPLC-UV method and drug plasma concentrations were modelled for each subject using a non-compartmental approach.3. amoxicillin showed rapid absorption after a single-dose treatment, with an elimination half-life of approximately 1 h. C, T and AUC values differed statistically between groups I and II (after the first dose administered). A large variability was observed in the pharmacokinetic profiles and drug accumulation may occur after the multiple administration.4. No accumulation in plasma was predicted from an simulation performed using the same multiple dosage schedule. The simulation does not seem to accurately predict in-field conditions.

摘要

尽管阿莫西林具有广谱抗菌活性，并且在禽类中广泛使用，但从未在鹅中对其进行过研究。本研究旨在评估鹅单次和多次口服阿莫西林后的药代动力学。
本研究共纳入 20 只鹅，并随机分为两组（每组 10 只）。在第 I 组中，动物接受单次口服 20 mg/kg 剂量的阿莫西林治疗，而第 II 组的鹅则接受多次剂量（4 天每天 20 mg/kg）。使用经过验证的 HPLC-UV 方法分析血浆中的阿莫西林浓度，并使用非房室模型对每个个体的药物血浆浓度进行建模。
单次给药后，阿莫西林吸收迅速，消除半衰期约为 1 小时。组 I 和组 II 之间（首次给药后）C、T 和 AUC 值存在统计学差异。药代动力学特征存在较大的变异性，多次给药后可能会发生药物蓄积。
使用相同的多次给药方案进行模拟预测，在血浆中不会发生蓄积。该模拟似乎无法准确预测现场条件。