Oktaviani Dian Paramita, Soebadi Mohammad Ayodhia, Kloping Yudhistira Pradnyan, Hidayatullah Furqan, Rahman Zakaria Aulia, Soetojo Soetojo
Department of Urology, Universitas Airlangga Faculty of Medicine, Dr. Soetomo General- Academic Hospital, Surabaya, Indonesia.
Department of Urology, Universitas Airlangga Faculty of Medicine, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia.
Turk J Urol. 2021 Sep;47(5):366-374. doi: 10.5152/tud.2021.21182.
Pain and discomfort may occur in catheterization during a urodynamic examination. A lidocaine gel combined with a water-based lubricant is sometimes used to reduce pain during catheterization. Several studies claimed that intraurethral lidocaine administration could cause inaccurate urodynamic parameters results. However, its definite effects in urodynamics testing on humans are still not clear. We aimed to evaluate the effects of intraurethral lidocaine on pain and urodynamic study parameters in patients undergoing an invasive urodynamic examination. A systematic search adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was performed in the MEDLINE, PubMed, and ScienceDirect databases for randomized controlled trials (RCTs). The bias of the studies is evaluated using the Cochrane risk of bias tool by two independent reviewers. The analyses of continuous outcomes were displayed as mean difference (MD), whereas odds ratio is used to analyze dichotomous data. Heterogeneity between studies is determined using the I2 value. A total of three RCTs out of 622 discovered that articles were eligible for analysis. Forest plot analysis of the mean visual analogue scale difference of the studies indicated an insignificant difference between the lidocaine and placebo group (MD -7.68; 95% CI -34.04 to -18.68, P ¼ .57). All urodynamic parameter results were also similar between the two groups (P > .05). Routine intraurethral lidocaine injection prior to a urodynamic study does not affect pain intensity and urodynamic parameters.
在尿动力学检查期间进行导尿时可能会出现疼痛和不适。有时会使用利多卡因凝胶与水基润滑剂相结合来减轻导尿过程中的疼痛。几项研究称，尿道内给予利多卡因可能会导致尿动力学参数结果不准确。然而，其在人体尿动力学测试中的明确效果仍不清楚。我们旨在评估尿道内利多卡因对接受侵入性尿动力学检查患者的疼痛和尿动力学研究参数的影响。按照系统评价和Meta分析的首选报告项目（PRISMA）方案，在MEDLINE、PubMed和ScienceDirect数据库中对随机对照试验（RCT）进行了系统检索。由两名独立 reviewers 使用Cochrane偏倚风险工具评估研究的偏倚。连续结果的分析以平均差（MD）表示，而比值比用于分析二分数据。使用I2值确定研究之间的异质性。在发现的622篇文章中，共有三项RCT符合分析条件。对这些研究的平均视觉模拟量表差异进行的森林图分析表明，利多卡因组和安慰剂组之间差异不显著（MD -7.68；95% CI -34.04至-18.68，P¼.57）。两组之间所有尿动力学参数结果也相似（P>.05）。在尿动力学研究前常规尿道内注射利多卡因不会影响疼痛强度和尿动力学参数。
