Dann J G, Stammers D K, Harris C J, Arrowsmith R J, Davies D E, Hardy G W, Morton J A
Biochem Biophys Res Commun. 1986 Jan 14;134(1):71-7. doi: 10.1016/0006-291x(86)90528-0.
A new class of human renin inhibitor is described, containing a novel analogue of the peptide bond. High inhibitory potency was observed for octapeptide-length substrate analogues but inhibition progressively weakened as the molecule was shortened from the amino terminal end.
描述了一类新型的人肾素抑制剂,其含有肽键的新型类似物。对于八肽长度的底物类似物观察到高抑制效力,但随着分子从氨基末端缩短,抑制作用逐渐减弱。