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地塞米松对脂肪组织中脂蛋白脂肪酶合成的调节作用。

Regulation of the synthesis of lipoprotein lipase in adipose tissue by dexamethasone.

作者信息

Speake B K, Parkin S M, Robinson D S

出版信息

Biochim Biophys Acta. 1986 Mar 19;881(1):155-7. doi: 10.1016/0304-4165(86)90109-1.

DOI:10.1016/0304-4165(86)90109-1
PMID:3511970
Abstract

The incorporation of [3H]leucine into lipoprotein lipase during incubations of rat epididymal fat-bodies in vitro was significantly stimulated by dexamethasone, whereas total protein synthesis was unaffected. The stimulation by dexamethasone required the presence of insulin. The results suggest that dexamethasone, in the presence of insulin, may specifically induce lipoprotein lipase synthesis in adipose tissue.

摘要

在体外培养大鼠附睾脂肪体的过程中,地塞米松显著刺激了[3H]亮氨酸掺入脂蛋白脂肪酶,而总蛋白质合成未受影响。地塞米松的刺激作用需要胰岛素的存在。结果表明,在胰岛素存在的情况下,地塞米松可能特异性诱导脂肪组织中脂蛋白脂肪酶的合成。

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引用本文的文献

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Stimulation of lipoprotein lipase synthesis by refeeding, insulin and dexamethasone.再喂养、胰岛素和地塞米松对脂蛋白脂肪酶合成的刺激作用。
Biochem J. 1993 Jun 1;292 ( Pt 2)(Pt 2):525-30. doi: 10.1042/bj2920525.
2
Relationship between lipoprotein lipase activity and plasma sex steroid level in obese women.肥胖女性脂蛋白脂肪酶活性与血浆性激素水平之间的关系。
J Clin Invest. 1988 Sep;82(3):1106-12. doi: 10.1172/JCI113667.
3
Interactions of insulin and dexamethasone in the control of pyruvate kinase activity and glucose metabolism in sheep adipose tissue.
胰岛素与地塞米松在调控绵羊脂肪组织丙酮酸激酶活性及葡萄糖代谢中的相互作用
Biochem J. 1987 Oct 15;247(2):459-65. doi: 10.1042/bj2470459.
4
Regulation of lipoprotein lipase activity and mRNA content in rat epididymal adipose tissue in vitro by recombinant tumour necrosis factor.重组肿瘤坏死因子对大鼠附睾脂肪组织脂蛋白脂肪酶活性及mRNA含量的体外调节
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