Hunter G J, Hunter J V, Brown N J
Br J Radiol. 1986 Jan;59(697):7-11. doi: 10.1259/0007-1285-59-697-7.
Digital subtraction angiography following an injection of iodinated contrast material can regularly produce good quality images. In addition to the conventional anatomical information, the timed sequence of digital images also contains useful temporal information which hitherto has been largely ignored. A simple method of image processing is described which utilises this timing information and presents it as a colour-coded set of functional images. Three parameters MAX, T-MAX and T-1/2 MAX are extracted from time-density curves, analogous to the time-activity curves of Nuclear Medicine, on a pixel-by-pixel basis. These parameters are used as a measure of overall organ perfusion, blood transit time between different vascular compartments, and as an indication of the initial delivery of contrast material to an organ. They have found use in the analysis of myocardial perfusion, before and after pharmacological intervention, and in the examination of the cerebral and renal circulations. The potential advantages of this technique derive from its superior spatial, temporal and contrast resolution.
注射碘化造影剂后的数字减影血管造影通常能够生成高质量的图像。除了传统的解剖学信息外，数字图像的定时序列还包含有用的时间信息，而这些信息迄今为止在很大程度上被忽视了。本文描述了一种简单的图像处理方法，该方法利用此定时信息并将其呈现为一组彩色编码的功能图像。类似于核医学的时间-活性曲线，从时间-密度曲线逐像素地提取三个参数MAX、T-MAX和T-1/2 MAX。这些参数用作衡量整体器官灌注、不同血管腔室之间的血液通过时间以及造影剂向器官初始输送的指标。它们已被用于药理干预前后心肌灌注的分析，以及脑循环和肾循环的检查。该技术的潜在优势源于其卓越的空间、时间和对比度分辨率。
