苦豆子中的抗肿瘤生物碱。
Anti-tumor alkaloids from Peganum harmala.
机构信息
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, PR China.
出版信息
Phytochemistry. 2022 May;197:113107. doi: 10.1016/j.phytochem.2022.113107. Epub 2022 Feb 1.
Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC values of 16.45 μM and 17.27 μM, respectively.
从骆驼蓬（Peganum harmala L.）的地上部分分离得到了 6 种生物碱 peharmalines F-K 以及 14 种已知生物碱。根据高分辨电喷雾质谱（HR-ESI-MS）数据、广泛的 NMR 谱学分析和 ECD 计算确定了分离化合物的结构。3-(4-羟基苯基)喹啉对 HepG-2 细胞系表现出很强的增殖抑制活性，IC 值为 3.05 μM。去氢骆驼蓬碱对 A549 和 HepG-2 细胞的抑制作用适中，IC 值分别为 16.45 μM 和 17.27 μM。
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