Wang Chun-Hua, Zeng Hong, Wang Yi-Hai, Li Chuan, Cheng Jun, Ye Zhi-Jun, He Xiang-Jiu
a School of Pharmaceutical Sciences, Wuhan University , Wuhan 430071 , China.
J Asian Nat Prod Res. 2015 May;17(5):595-600. doi: 10.1080/10286020.2015.1042373.
A phytochemical study on the methanol extracts from the seeds of Peganum harmala L. led to a new quizonaline alkaloid (S)-vasicinone-1-O-β-d-glucopyranoside (1) and four known ones, (R)-vasicinone-1-O-β-d-glucopyranoside (2), (S)-vasicinone (3), vasicine (4), and deoxyvasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.
对骆驼蓬种子甲醇提取物进行的植物化学研究，得到了一种新的喹唑啉生物碱（S）-鸭嘴花酮碱-1-O-β-D-吡喃葡萄糖苷（1）和四种已知生物碱，即（R）-鸭嘴花酮碱-1-O-β-D-吡喃葡萄糖苷（2）、（S）-鸭嘴花酮碱（3）、鸭嘴花碱（4）和脱氧鸭嘴花酮碱（5）。通过包括红外光谱（IR）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D和2D NMR）以及旋光测定等光谱分析，并将数据与文献中的数据进行比较，阐明了它们的结构。采用MTT法对所有生物碱进行了抗人胃癌细胞MCG-803增殖活性的筛选。化合物1和3表现出中等抑制活性。
