一项针对社区居住的老年人骨质疏松症、骨折风险因素和药物使用情况的患病率更新：来自加拿大老龄化纵向研究（CLSA）的结果。
An update of the prevalence of osteoporosis, fracture risk factors, and medication use among community-dwelling older adults: results from the Canadian Longitudinal Study on Aging (CLSA).
机构信息
School of Physiotherapy, Dalhousie University, Forrest Building, P.O. Box 15000, Halifax, NS, B3H 4R2, Canada.
GERAS Centre for Aging Research, Hamilton, Ontario, Canada.
出版信息
Arch Osteoporos. 2022 Feb 4;17(1):31. doi: 10.1007/s11657-022-01073-1.
UNLABELLED
The prevalence of self-reported and DXA-confirmed osteoporosis was 7.8% (males 2.2%; females 12.7%), and 3.6% (males 1.2%; females 5.9%), respectively. We found that most community-dwelling older adults at high fracture risk are not taking osteoporosis medication, particularly males. There is a major opportunity for improved primary fracture prevention in the community.
PURPOSE
To provide an up-to-date prevalence estimate of osteoporosis, fracture risk factors, fracture risk, and the proportion of older Canadians at high fracture risk who are not taking an osteoporosis medication.
METHODS
We included Canadian Longitudinal Study on Aging (CLSA) participants: a community-dwelling cohort aged 45 to 85 years who completed the baseline (2015) comprehensive interview and had dual-energy X-ray absorptiometry (DXA) scans (N = 30,097). We describe the age- and sex-stratified prevalence of (1) self-reported osteoporosis; (2) DXA-confirmed osteoporosis; (3) fracture risk factors and people who are at high risk (FRAX® major osteoporotic fracture probability ≥ 20%); and (4) people who are at high fracture risk not taking osteoporosis medications. Sampling weights, as defined by the CLSA, were applied.
RESULTS
The mean age of participants was 70.0 (SD 10.3). Overall, 7.8% had self-reported osteoporosis (males 2.2%; females 12.7%) while 3.6% had DXA-confirmed osteoporosis (males 1.2%; females 5.9%), and 2.8% were at high fracture risk (males 0.3%; females 5.1%). Of people who had osteoporosis and were at high risk, 77.3% were not taking an osteoporosis medication (males 92.3%; females 76.8%).
CONCLUSIONS
Our study provides an up-to-date prevalence estimate of osteoporosis for community-dwelling older Canadians. We found that most community-dwelling older adults at high fracture risk are not taking an osteoporosis medication, particularly males. There is a major opportunity for improved primary fracture prevention in the community.
未注明
自我报告和 DXA 确诊的骨质疏松症的患病率分别为 7.8%（男性 2.2%；女性 12.7%）和 3.6%（男性 1.2%；女性 5.9%）。我们发现，大多数处于高骨折风险的社区居住老年人并未服用骨质疏松症药物，尤其是男性。在社区中，有机会改善初级骨折预防。
目的
提供骨质疏松症、骨折危险因素、骨折风险以及未服用骨质疏松症药物的高骨折风险加拿大老年人比例的最新患病率估计。
方法
我们纳入了加拿大老龄化纵向研究（CLSA）的参与者：年龄在 45 至 85 岁之间的社区居住队列，他们完成了基线（2015 年）综合访谈并进行了双能 X 线吸收法（DXA）扫描（N=30097）。我们描述了（1）自我报告的骨质疏松症；（2）DXA 确诊的骨质疏松症；（3）骨折危险因素和高风险人群（FRAX®主要骨质疏松性骨折概率≥20%）；以及（4）未服用骨质疏松症药物的高骨折风险人群。应用了 CLSA 定义的抽样权重。
结果
参与者的平均年龄为 70.0（SD 10.3）岁。总体而言，7.8%的人自我报告患有骨质疏松症（男性 2.2%；女性 12.7%），3.6%的人 DXA 确诊患有骨质疏松症（男性 1.2%；女性 5.9%），2.8%的人处于高骨折风险（男性 0.3%；女性 5.1%）。患有骨质疏松症和高风险的人群中，77.3%未服用骨质疏松症药物（男性 92.3%；女性 76.8%）。
结论
我们的研究为加拿大社区居住的老年人提供了骨质疏松症的最新患病率估计。我们发现，大多数处于高骨折风险的社区居住老年人并未服用骨质疏松症药物，尤其是男性。在社区中，有机会改善初级骨折预防。
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