Marrero P F, Haro D, Hegardt F G
FEBS Lett. 1986 Mar 3;197(1-2):183-6. doi: 10.1016/0014-5793(86)80323-4.
Incubation of rat hepatocytes with 10 mM mevalonate produces a decrease in HMG-CoA reductase activity and in the rate of synthesis of both monomeric and dimeric HMG-CoA reductase, and an increase in the rate of degradation of the monomeric form without significant change in that of the dimeric form. Since mevalonate promotes a short-term phosphorylation of the monomeric form without affecting the dimeric form, it is suggested that the mechanism of degradation of reductase is controlled by its phosphorylation state.
用10 mM甲羟戊酸孵育大鼠肝细胞会导致HMG - CoA还原酶活性降低，单体和二聚体HMG - CoA还原酶的合成速率下降，单体形式的降解速率增加，而二聚体形式的降解速率无显著变化。由于甲羟戊酸促进单体形式的短期磷酸化而不影响二聚体形式，因此提示还原酶的降解机制受其磷酸化状态控制。
