[骨髓基质细胞在急性淋巴细胞白血病中作用的研究进展——综述]
[Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia --Review].
作者信息
Kang Jun-Nan, Chen Ze-Hui, Tian Chen
机构信息
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China,E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Feb;30(1):319-322. doi: 10.19746/j.cnki.issn.1009-2137.2022.01.053.
Acute lymphoblastic leukemia (ALL) is a kind of the most common hematopoietic malignancy, its recurrence and drug resistance are closely related to the bone marrow microenvironment. Bone marrow stromal cell (BMSC) is an important part of the bone marrow microenvironment and their interaction with leukemia cells cannot be ignored. BMSC participates in and regulate signaling pathways related to proliferation or apoptosis of ALL cells by secretes cytokines or extracellular matrix proteins, thus affecting the survival of ALL cells. In this review, the research advance of several signaling pathways of the interaction between BMSC and ALL cells was summarized briefly.
急性淋巴细胞白血病（ALL）是最常见的造血系统恶性肿瘤之一，其复发和耐药与骨髓微环境密切相关。骨髓基质细胞（BMSC）是骨髓微环境的重要组成部分，它们与白血病细胞的相互作用不容忽视。BMSC通过分泌细胞因子或细胞外基质蛋白参与并调节与ALL细胞增殖或凋亡相关的信号通路，从而影响ALL细胞的存活。本文简要综述了BMSC与ALL细胞相互作用的几种信号通路的研究进展。
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