Laboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3(th) floor, 26006 Logroño, Spain.
Laboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3(th) floor, 26006 Logroño, Spain.
Neurobiol Dis. 2022 May;166:105651. doi: 10.1016/j.nbd.2022.105651. Epub 2022 Feb 3.
Although the factors contributing to the pathogenesis of neurodegenerative diseases remain elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of neurodegenerative diseases. The link between endolysosomal dysfunction and neurodegeneration is supported by genetic studies identifying disease mutations in genes controlling endolysosomal function. Growing evidence suggests that endolysosomal dysfunction affect the production, secretion and content of exosomes. Current data suggests that exosomes play a key role in Parkinson's disease (PD) and Alzheimer's disease (AD) progression, interfering with the transmission of pathological proteins or neuroinflammatory factors related to neurodegenerative diseases. This review summarizes recent advances in the role of endolysosomal dysfunction in the spreading of pathological proteins mediated by exosomes in the two most common neurodegenerative diseases, AD and PD.
虽然导致神经退行性疾病发病机制的因素仍不清楚，但内溶酶体途径正在成为神经退行性疾病发病机制中的关键因素。内溶酶体功能障碍与神经退行性变之间的联系得到了遗传研究的支持，这些研究鉴定了控制内溶酶体功能的基因中的疾病突变。越来越多的证据表明，内溶酶体功能障碍会影响外体的产生、分泌和内容物。目前的数据表明，外体在帕金森病 (PD) 和阿尔茨海默病 (AD) 的进展中发挥着关键作用，干扰与神经退行性疾病相关的病理蛋白或神经炎症因子的传递。这篇综述总结了内溶酶体功能障碍在两种最常见的神经退行性疾病 AD 和 PD 中外体介导的病理蛋白传播中的作用的最新进展。
