Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 May 5;272:120955. doi: 10.1016/j.saa.2022.120955. Epub 2022 Jan 29.
Surface-enhanced Raman scattering (SERS), due to its high detecting sensitivity and rapid data acquisition ability, has been considered as a powerful technique for label-free ultrasensitive detection of chemical and biochemical analytes. As an important part, the uniform SERS substrate is the prerequisite for this technology being used in all the related areas. Therefore, seeking the fast, convenient and low-cost way to obtain the SERS substrate with high performance and reproducibility never stops in recent decades. In this work, the PC membrane with uniform nanopores obtained by ion irradiation and chemical etching (i.e., ion-track etched PC membrane) was first used to prepare the gold nanostar SERS substrate. The monolayer gold nanostars can be obtained through a one-step redox reaction on the surface of the PC membrane, which not only can act as the base of SERS substrate but also can work as the reaction adjuster. By optimizing the growth conditions, the SERS substrate with uniform monolayer gold nanostars can be fabricated without any complicated procedures and costly equipment fast (in 20 mins). Meanwhile, the prepared flexible gold nanostar SERS substrate exhibits excellent Raman performance, which can effectively detect the analyte R6G with the concentration as low as 1 × 10 M and the SERS enhancement factors can be around 3.70 × 10. The new facile SERS substrate preparation method is cost-effective, convenient, fast and easily scale up, which can satisfy the requests of the real applications in many fields.
表面增强拉曼散射（SERS）由于其高检测灵敏度和快速数据采集能力，被认为是一种用于化学和生物化学分析物无标记超灵敏检测的强大技术。作为一个重要部分，均匀的 SERS 基底是该技术在所有相关领域应用的前提。因此，寻找快速、方便和低成本的方法来获得具有高性能和可重现性的 SERS 基底，在最近几十年从未停止过。在这项工作中，首先使用通过离子辐照和化学刻蚀（即离子轨迹刻蚀 PC 膜）获得的具有均匀纳米孔的 PC 膜来制备金纳米星 SERS 基底。通过 PC 膜表面的一步氧化还原反应可以获得单层金纳米星，它不仅可以作为 SERS 基底的基础，还可以作为反应调节剂。通过优化生长条件，可以快速（在 20 分钟内）制备具有均匀单层金纳米星的 SERS 基底，而无需任何复杂的程序和昂贵的设备。同时，所制备的柔性金纳米星 SERS 基底表现出优异的拉曼性能，可以有效地检测浓度低至 1×10 M 的分析物 R6G，SERS 增强因子约为 3.70×10。这种新的简便 SERS 基底制备方法具有成本效益高、方便、快速且易于规模化，能够满足许多领域实际应用的需求。
