Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA.
J Alzheimers Dis. 2022;86(2):763-771. doi: 10.3233/JAD-215148.
Financial capacity (FC) is a complex ability commonly impaired in older individuals with cognitive impairment; however, the underlying neural mechanisms are not well understood.
To assess resting state functional connectivity using functional magnetic resonance imaging (rs-fMRI) in individuals with mild cognitive impairment (MCI) and impaired FC compared to cognitively normal older adults.
rs-fMRI scans were obtained from individuals with MCI (N = 17) and normal older adults (N = 15). All participants completed the Financial Capacity Instrument Short Form (FCI-SF) and neuropsychological assessments. Based on previous findings, the left angular gyrus (lAG) was used as the seed region. Connectivity correlation coefficients were calculated for each seed-based connection that showed significantly altered connectivity. A Pearson's correlation was calculated between the connectivity correlation values from relevant regions and FC and other cognitive measures.
A total of 26 brain regions showed significantly increased functional connectivity with the lAG. Of these regions, 14 were identified as relevant to higher-level cognitive function for analysis. Pearson's correlations showed a significant negative correlation between the FCI-SF total score and increased connectivity between the IAG and the right temporal fusiform cortex (rTFC) (r = -0.455, p = 0.009).
Results showed a significant correlation between FC and increased functional connectivity between the lAG and the rTFC in cognitively normal older adults compared to participants with MCI. These exploratory findings suggest that cognitive functions play important roles in FC as the functional connectivity between the lAG and rTFC was not associated with other tests of executive or visuospatial cognition.
财务能力（FC）是认知障碍老年人普遍受损的复杂能力；然而，其潜在的神经机制尚不清楚。
使用功能磁共振成像（rs-fMRI）评估轻度认知障碍（MCI）个体与认知正常老年人相比 FC 受损的静息状态功能连接。
从 MCI 患者（N=17）和认知正常老年人（N=15）中获取 rs-fMRI 扫描。所有参与者都完成了财务能力量表短表（FCI-SF）和神经心理学评估。基于先前的发现，左侧角回（lAG）被用作种子区域。为每个种子连接计算相关性系数，这些种子连接显示出明显改变的连接。对来自相关区域的连接相关性值与 FC 和其他认知测量值之间进行 Pearson 相关性计算。
共有 26 个大脑区域与 lAG 显示出明显增加的功能连接。在这些区域中，有 14 个被确定为与高级认知功能相关的区域进行分析。Pearson 相关性分析显示，FCI-SF 总分与 lAG 与右侧颞枕联合区（rTFC）之间增加的连接之间存在显著负相关（r=-0.455，p=0.009）。
结果显示，认知正常老年人的 FC 与 lAG 与 rTFC 之间增加的功能连接之间存在显著相关性，而与 MCI 参与者相比则没有。这些探索性发现表明，认知功能在 FC 中起着重要作用，因为 lAG 与 rTFC 之间的功能连接与其他执行或视觉空间认知测试无关。
