Basałygo Magdalena, Śliwińska Joanna, Żbikowska-Gotz Magdalena, Lis Kinga, Socha Ewa, Nowowiejska Laura, Bartuzi Zbigniew, Zegarska Barbara
Department of Cosmetology and Aesthetic Dermatology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Department and Clinic of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatol Alergol. 2021 Dec;38(6):1071-1077. doi: 10.5114/ada.2021.109686. Epub 2021 Oct 26.
Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory effects, and its biological function of reciprocal epidermal hyperplasia and of inhibiting the filaggrin synthesis points to an essential role connecting the inflammatory process with damage to the epidermal barrier in the course of atopic dermatitis (AD).
To assess the IL-25 in serum concentration in AD patients and to analyse its possible correlation with the disease intensity and selected epidermal barrier parameters such as transepidermal water loss (TEWL).
The study involved 43 patients with AD and 22 healthy volunteers. The IL-25 concentration was measured using the ELISA method. The intensity of disease symptoms was investigated using W-AZS and EASI indicators. The epidermal barrier was evaluated using a Tewameter TM300 and Corneometer CM825.
The concentration of IL-25 in serum was higher in the study group than in the control group. IL-25 serum concentration correlates with W-AZS/EASI in patients with a severe and moderate course of AD. The concentration of IL-25 affects the TEWL within the affected, evaluated skin surface.
An elevated IL-25 concentration in serum is characteristic for patients with moderate and severe AD intensity. The IL-25 concentration in serum correlates with TEWL and with the moisture level in the affected area. However, further studies are necessary to determine the role played by IL-25 in the course of the disease and how it affects the functional parameters of the epidermal barrier.
白细胞介素25（IL - 25）是一种具有促炎和抗炎作用的细胞因子，其在表皮增生和抑制丝聚合蛋白合成方面的生物学功能表明，在特应性皮炎（AD）病程中，它在连接炎症过程与表皮屏障损伤方面起着重要作用。
评估AD患者血清中IL - 25的浓度，并分析其与疾病严重程度以及所选表皮屏障参数（如经表皮水分流失（TEWL））之间的可能相关性。
该研究纳入了43例AD患者和22名健康志愿者。采用ELISA法测定IL - 25浓度。使用W - AZS和EASI指标调查疾病症状的严重程度。使用Tewameter TM300和Corneometer CM825评估表皮屏障。
研究组血清中IL - 25的浓度高于对照组。在AD病情严重和中度的患者中，IL - 25血清浓度与W - AZS/EASI相关。IL - 25的浓度会影响所评估的患部皮肤表面的TEWL。
血清中IL - 25浓度升高是中重度AD患者的特征。血清中IL - 25浓度与TEWL以及患部的水分水平相关。然而，需要进一步研究以确定IL - 25在疾病病程中所起的作用以及它如何影响表皮屏障的功能参数。
