Department of Pharmacy, Yantaishan Hospital, Yantai 26400, China.
Department of Health Materials Management, Dongying People's Hospital, Dongying Hospital Affiliated to Shandong Provincial Hospital Group, Dongying 257091, China.
J Healthc Eng. 2022 Jan 25;2022:1516633. doi: 10.1155/2022/1516633. eCollection 2022.
Current study aimed to investigate the benefits of adjuvant therapy with traditional Chinese medicine on the pediatric primary nephrotic syndrome.
A total of 455 patients with PNS admitted to our hospital from January 2010 to January 2019 were divided into the traditional Chinese medicine group ( = 217) and the control group ( = 238). The control group received conventional Western medical treatment, and the traditional Chinese medicine group was treated with traditional Chinese medicine supplemented with Western medical treatment. The differences in remission rate, recurrence rate, and recurrence-free survival between the two groups were evaluated.
The differences in clinical parameters between the two groups were not statistically significant. Compared with the control group, adjuvant treatment with traditional Chinese medicine increased the clinical remission rate (=0.037), decreased the relapse rate (=0.015), prolonged relapse-free survival ( ≤ 0.01), and was an independent protective factor for relapse-free survival in children with PNS (HR = 0.55, 95% CI 0.49-0.63, ≤ 0.01). In a subgroup analysis of the traditional Chinese medicine formulations, Yuebi Jiazhu Tang, Ganlu Xiaodu Dan, and Yupingfeng granules significantly reduced the risk of recurrence in children ( ≤ 0.01, ≤ 0.01, =0.003).
Adjuvant treatment of pediatric primary nephrotic syndrome with traditional Chinese medicine could benefit the children.
本研究旨在探讨中药辅助治疗小儿原发性肾病综合征的疗效。
选取 2010 年 1 月至 2019 年 1 月我院收治的 455 例 PNS 患儿，分为中药组（n=217）和对照组（n=238）。对照组给予常规西医治疗，中药组在西医治疗的基础上加用中药治疗。评价两组患儿的缓解率、复发率及无复发生存率的差异。
两组患儿的临床参数比较差异无统计学意义。与对照组相比，中药辅助治疗提高了临床缓解率（=0.037），降低了复发率（=0.015），延长了无复发生存时间（ ≤ 0.01），是 PNS 患儿无复发生存的独立保护因素（HR=0.55，95%CI 0.49-0.63， ≤ 0.01）。在中药方剂的亚组分析中，越婢加术汤、甘露消毒丹和玉屏风颗粒显著降低了患儿的复发风险（ ≤ 0.01， ≤ 0.01， =0.003）。
中药辅助治疗小儿原发性肾病综合征可使患儿获益。
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