对 . 蛋白衍生的 gp15 和 gp40 蛋白源性合成肽的血清 IgG 反应

Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From .

机构信息

Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, Mexico.

Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo A. C., Hermosillo, Mexico.

出版信息

Front Cell Infect Microbiol. 2022 Jan 19;11:810887. doi: 10.3389/fcimb.2021.810887. eCollection 2021.

DOI:10.3389/fcimb.2021.810887

PMID:35127561

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8807513/

Abstract

spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with , , and , and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.

摘要

spp. 是导致中度至重度腹泻的罪魁祸首，主要发生在儿童和免疫功能低下的患者中。本研究采用 ELISA 法，检测了感染、、和而未感染的患者血清 IgM 和 IgG 抗体对来自 gp40 和 gp15 蛋白序列的合成肽的识别。病例组和对照组在肽 A133 和 A32 的识别方面存在统计学差异（p = 0.0025）。需要进一步研究这些肽作为疫苗候选物的潜力。