• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1,3,4-噻二唑骨架：作为抗癫痫药物

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents.

作者信息

Anthwal Tulika, Nain Sumitra

机构信息

Department of Pharmacy, Banasthali Vidyapith, Banasthali, India.

出版信息

Front Chem. 2022 Jan 21;9:671212. doi: 10.3389/fchem.2021.671212. eCollection 2021.

DOI:10.3389/fchem.2021.671212
PMID:35127639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8814426/
Abstract

A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial. To date, drugs such as butazolamide, and acetazolamide. Several modifications have been done in the 1,3,4-thiadiazole moiety which showed good potency as anticonvulsant agents which are highly effective and have less toxicity. After in-depth literature survey in this review, we have compiled various derivatives of 1,3,4-thiadiazole scaffold as anticonvulsant agents.

摘要

1,3,4-噻二唑部分具有广泛的生物活性，如抗糖尿病、抗癌、抗炎、抗惊厥、抗病毒、抗高血压和抗菌活性。迄今为止，已有如布他唑胺和乙酰唑胺等药物。人们对1,3,4-噻二唑部分进行了多种修饰，这些修饰后的化合物作为抗惊厥剂显示出良好的效力，它们高效且毒性较小。在本次综述中进行深入的文献调研后，我们汇总了1,3,4-噻二唑骨架的各种衍生物作为抗惊厥剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/92269813909a/fchem-09-671212-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/850d2814aacf/fchem-09-671212-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/124bf0d45f94/fchem-09-671212-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/6739e0f19dc8/fchem-09-671212-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/d6955d249581/fchem-09-671212-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/a58fe7ca160d/fchem-09-671212-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/ade321457062/fchem-09-671212-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/76aa0fd08fbc/fchem-09-671212-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/bb4ab80521f4/fchem-09-671212-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/445ae5e7bb1a/fchem-09-671212-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/a8028f3fea7e/fchem-09-671212-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/2c790e41df8b/fchem-09-671212-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/cb624845fcd6/fchem-09-671212-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1ef1291b62be/fchem-09-671212-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/c12b24621695/fchem-09-671212-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/b74b9d6f0d6e/fchem-09-671212-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/30988451c880/fchem-09-671212-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/52534e2eec11/fchem-09-671212-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1291d612538c/fchem-09-671212-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/21189a401fed/fchem-09-671212-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1369b1b6914b/fchem-09-671212-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/4f542b6e2f98/fchem-09-671212-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/81cc460e7cd3/fchem-09-671212-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/513c1a7c33c9/fchem-09-671212-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/dee16ebd5a11/fchem-09-671212-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/4f5b4dce9fd6/fchem-09-671212-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/92269813909a/fchem-09-671212-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/850d2814aacf/fchem-09-671212-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/124bf0d45f94/fchem-09-671212-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/6739e0f19dc8/fchem-09-671212-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/d6955d249581/fchem-09-671212-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/a58fe7ca160d/fchem-09-671212-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/ade321457062/fchem-09-671212-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/76aa0fd08fbc/fchem-09-671212-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/bb4ab80521f4/fchem-09-671212-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/445ae5e7bb1a/fchem-09-671212-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/a8028f3fea7e/fchem-09-671212-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/2c790e41df8b/fchem-09-671212-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/cb624845fcd6/fchem-09-671212-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1ef1291b62be/fchem-09-671212-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/c12b24621695/fchem-09-671212-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/b74b9d6f0d6e/fchem-09-671212-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/30988451c880/fchem-09-671212-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/52534e2eec11/fchem-09-671212-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1291d612538c/fchem-09-671212-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/21189a401fed/fchem-09-671212-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/1369b1b6914b/fchem-09-671212-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/4f542b6e2f98/fchem-09-671212-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/81cc460e7cd3/fchem-09-671212-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/513c1a7c33c9/fchem-09-671212-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/dee16ebd5a11/fchem-09-671212-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/4f5b4dce9fd6/fchem-09-671212-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d90/8814426/92269813909a/fchem-09-671212-g026.jpg

相似文献

1
1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents.1,3,4-噻二唑骨架：作为抗癫痫药物
Front Chem. 2022 Jan 21;9:671212. doi: 10.3389/fchem.2021.671212. eCollection 2021.
2
Synthetic methods, chemistry, and the anticonvulsant activity of thiadiazoles.噻二唑的合成方法、化学性质及抗惊厥活性
Int J Med Chem. 2013;2013:348948. doi: 10.1155/2013/348948. Epub 2013 Apr 30.
3
Thiadiazole inhibitors: a patent review.噻二唑抑制剂：专利研究综述。
Expert Opin Ther Pat. 2017 Apr;27(4):477-505. doi: 10.1080/13543776.2017.1272575. Epub 2017 Jan 4.
4
Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold.含1,3,4-噻二唑骨架的杨梅素衍生物的合成及其生物活性
Chem Cent J. 2017 Oct 17;11(1):106. doi: 10.1186/s13065-017-0336-7.
5
1,3,4-thiadiazole and its derivatives: a review on recent progress in biological activities.1,3,4-噻二唑及其衍生物：生物活性的最新研究进展综述。
Chem Biol Drug Des. 2013 May;81(5):557-76. doi: 10.1111/cbdd.12125.
6
Thiadiazole-a promising structure in medicinal chemistry.噻二唑——药物化学中极具前景的结构。
ChemMedChem. 2013 Jan;8(1):27-41. doi: 10.1002/cmdc.201200355. Epub 2012 Dec 3.
7
Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review.基于人癌细胞系的1,3,4-噻二唑及其稠环的研究方法：综述
Anticancer Agents Med Chem. 2017;17(4):500-523. doi: 10.2174/1871520616666161013150151.
8
Recent progress in biological activities of synthesized phenothiazines.合成吩噻嗪类化合物的生物活性研究进展。
Eur J Med Chem. 2011 Aug;46(8):3179-89. doi: 10.1016/j.ejmech.2011.05.013. Epub 2011 May 12.
9
A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review.5-吡唑酮作为多功能支架的治疗之旅：综述。
Mini Rev Med Chem. 2021;21(13):1770-1795. doi: 10.2174/1389557521999210101224058.
10
Thiadiazole derivatives as anticancer agents.噻二唑衍生物作为抗癌剂。
Pharmacol Rep. 2020 Oct;72(5):1079-1100. doi: 10.1007/s43440-020-00154-7. Epub 2020 Sep 3.

引用本文的文献

1
Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment.硫酸镁对尼可刹米诱发癫痫的预防和治疗作用：对COVID-19治疗的启示
World J Methodol. 2025 Dec 20;15(4):105775. doi: 10.5662/wjm.v15.i4.105775.
2
2-[(5-Methyl-1,3,4-thia-diazol-2-yl)sulfan-yl]-'-(4-nitro-benzyl-idene)acetohydrazide monohydrate.2-[(5-甲基-1,3,4-噻二唑-2-基)硫基]-1-(4-硝基亚苄基)乙酰肼一水合物
IUCrdata. 2025 Apr 24;10(Pt 4):x250364. doi: 10.1107/S2414314625003645. eCollection 2025 Apr.
3
Recent Progress in Thiazole, Thiosemicarbazone, and Semicarbazone Derivatives as Antiparasitic Agents Against Trypanosomatids and spp.

本文引用的文献

1
Biological evaluation and molecular docking of novel 1,3,4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors.新型 1,3,4-噻二唑-间苯二酚缀合物作为多功能胆碱酯酶抑制剂的生物学评价和分子对接。
Bioorg Chem. 2021 Feb;107:104617. doi: 10.1016/j.bioorg.2020.104617. Epub 2021 Jan 5.
2
Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives-A Review.1,3,4-噻二唑衍生物的细胞毒性性质综述。
Molecules. 2020 Sep 20;25(18):4309. doi: 10.3390/molecules25184309.
3
Synthesis and radioligand-binding assay of 2,5-disubstituted thiadiazoles and evaluation of their anticonvulsant activities.
噻唑、缩氨基硫脲和氨基脲衍生物作为抗锥虫和其他物种抗寄生虫剂的最新进展
Molecules. 2025 Apr 16;30(8):1788. doi: 10.3390/molecules30081788.
4
Safety assessment of novel oxadiazole derivatives in acute and sub-acute toxicity studies.新型恶二唑衍生物在急性和亚急性毒性研究中的安全性评估。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):3631-3653. doi: 10.1007/s00210-024-03474-0. Epub 2024 Oct 1.
5
Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles.2-巯基-5-甲基-1,3,4-噻二唑的官能化：2-(ω-卤代烷硫基)噻二唑与对称双噻二唑
Molecules. 2024 Apr 24;29(9):1938. doi: 10.3390/molecules29091938.
6
An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives as potential inhibitors of SARS-CoV-2 proteases: drug-likeness, pharmacophore, molecular docking, and DFT exploration.一些新型螺环-N-(4-氨磺酰基苯基)-1,3,4-噻二唑-2-甲酰胺衍生物作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）蛋白酶潜在抑制剂的高效、环保、简单且绿色的合成：类药性、药效团、分子对接及密度泛函理论研究
Mol Divers. 2024 Feb;28(1):249-270. doi: 10.1007/s11030-023-10761-0. Epub 2023 Nov 9.
7
2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential.2-取代-3-(5-取代-1,3,4-恶二唑/噻二唑-2-基)噻唑烷-4-酮衍生物：合成、抗癌、抗菌及抗氧化潜力
Pharmaceuticals (Basel). 2023 May 29;16(6):805. doi: 10.3390/ph16060805.
8
An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors.对基于机制的1,3,4-恶二唑支架作为细胞毒性剂和酶抑制剂的方法的理解。
Pharmaceuticals (Basel). 2023 Feb 7;16(2):254. doi: 10.3390/ph16020254.
2,5-取代噻二唑的合成及放射配体结合分析及其抗惊厥活性评价。
Arch Pharm (Weinheim). 2020 Dec;353(12):e2000066. doi: 10.1002/ardp.202000066. Epub 2020 Aug 27.
4
Novel 5-(nitrothiophene-2-yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity against promastigote stage of Leishmania major.新型5-（硝基噻吩-2-基）-1,3,4-噻二唑衍生物：针对硕大利什曼原虫前鞭毛体阶段的合成及抗利什曼活性
Iran J Pharm Res. 2019 Fall;18(4):1816-1822. doi: 10.22037/ijpr.2019.14547.12476.
5
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections.含 2-氨基-1,3,4-噻二唑片段的合成化合物抗病毒感染。
Molecules. 2020 Feb 19;25(4):942. doi: 10.3390/molecules25040942.
6
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.新型 1,3,4-噻二唑类 DDX3X 抑制剂的合成与抗病毒活性。
Molecules. 2019 Nov 4;24(21):3988. doi: 10.3390/molecules24213988.
7
Heterocycles 48. Synthesis, Characterization and Biological Evaluation of Imidazo[2,1-][1,3,4]Thiadiazole Derivatives as Anti-Inflammatory Agents.杂环化合物 48. 作为抗炎剂的咪唑并[2,1-][1,3,4]噻二唑衍生物的合成、表征和生物评价。
Molecules. 2018 Sep 21;23(10):2425. doi: 10.3390/molecules23102425.
8
2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents.2-氨基-1,3,4-噻二唑作为一种有潜力的抗菌剂骨架。
Drug Des Devel Ther. 2018 May 31;12:1545-1566. doi: 10.2147/DDDT.S155958. eCollection 2018.
9
Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.嘧啶基 1,3,4-噁二唑、1,3,4-噻二唑和 1,2,4-三唑的合成及抗菌活性。
Eur J Med Chem. 2018 Feb 10;145:1-10. doi: 10.1016/j.ejmech.2017.12.067. Epub 2017 Dec 21.
10
A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety.一些带有1,3,4-噻二唑部分的新型噻唑的简便合成及其抗癌活性
Chem Cent J. 2017 Mar 21;11(1):25. doi: 10.1186/s13065-017-0255-7.