Yin Lu, Qi Yuan, Ge Zhiru, Li Jiajin
Department of Cardiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200000, China.
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Open Life Sci. 2022 Jan 28;17(1):1-9. doi: 10.1515/biol-2022-0002. eCollection 2022.
The aim of this study was to explore the effects of dabigatran and rivaroxaban on the activities of various coagulation factors. To achieve that, 60 rabbits were randomly divided into experimental groups that received different doses of dabigatran or rivaroxaban. The effects of dabigatran and rivaroxaban on the activities of FII, FV, FVIII, FX, and activated protein C (APC) were analyzed. In the dabigatran groups, activated partial thromboplastin time and thromboplastin time (TT) were prolonged after drug administration, and the activities of FII, FV, FVIII, and FX were inhibited as the drug concentration increased. Low doses of dabigatran inhibited APC activity. In the rivaroxaban groups, APTT and TT were not significantly prolonged after drug administration. In contrast, the high-dose rivaroxaban group exhibited prolonged PT, and the degree of inhibition of the activities of FII, FV, FVIII, and FX increased as the drug concentration increased. Rivaroxaban had no significant effect on APC activity regardless of dosage. As the drug concentration increased, both NOACs had more significant inhibitory effects on the activities of FII, FV, FVIII, and FX. Low concentrations of dabigatran generated an inhibitory effect on APC activity, while high concentrations of dabigatran had no significant effect. Rivaroxaban had no significant effect on APC activity.
本研究的目的是探讨达比加群和利伐沙班对各种凝血因子活性的影响。为此，将60只兔子随机分为接受不同剂量达比加群或利伐沙班的实验组。分析了达比加群和利伐沙班对凝血因子II、V、VIII、X及活化蛋白C（APC）活性的影响。在达比加群组中，给药后活化部分凝血活酶时间和凝血酶时间（TT）延长，随着药物浓度增加，凝血因子II、V、VIII和X的活性受到抑制。低剂量达比加群抑制APC活性。在利伐沙班组中，给药后活化部分凝血活酶时间和凝血酶时间未显著延长。相反，高剂量利伐沙班组的凝血酶原时间延长，随着药物浓度增加，凝血因子II、V、VIII和X活性的抑制程度增加。利伐沙班对APC活性无论剂量大小均无显著影响。随着药物浓度增加，两种非维生素K拮抗剂对凝血因子II、V、VIII和X活性的抑制作用更显著。低浓度达比加群对APC活性产生抑制作用，而高浓度达比加群无显著影响。利伐沙班对APC活性无显著影响。
