Zampeli Evangelia, Zervas Eleftherios
Rheumatology Department, Lefkos Stavros - The Athens Clinic, Athens, Greece.
7 Pulmonary Department and Central Bronchoscopic Unit "Christos Gagas" NHS, Athens Chest Hospital "Sotiria", Athens, Greece.
Mediterr J Rheumatol. 2021 Dec 27;32(4):376-377. doi: 10.31138/mjr.32.4.376. eCollection 2021 Dec.
With the increasing number of indications for checkpoint inhibitor therapy in cancer patients, rheumatology specialists are often involved in the diagnosis and management of immune-related adverse events (irAEs). The most common rheumatic irAEs are arthritis, sicca syndrome, polymyalgia rheumatica, and myositis. Eosinophilic fasciitis, an already rare rheumatic disease, is a very unusual rheumatic irAE. Eosinophilic fasciitis, whether idiopathic or checkpoint inhibitor-associated, has very particular clinical symptoms and findings, such as the orange peel skin appearance and the Groove sign, which the physicians need to be aware of and recognise timely in order to diminish morbidity.
随着癌症患者中检查点抑制剂治疗适应证的增加，风湿病专科医生常常参与免疫相关不良事件（irAE）的诊断和管理。最常见的风湿性irAE是关节炎、干燥综合征、风湿性多肌痛和肌炎。嗜酸性筋膜炎，一种本就罕见的风湿性疾病，是一种非常不寻常的风湿性irAE。嗜酸性筋膜炎，无论是特发性的还是与检查点抑制剂相关的，都有非常特殊的临床症状和表现，如橘皮样皮肤外观和沟槽征，医生需要及时了解并认识到这些，以降低发病率。
