81748ICMR-National AIDS Research Institute, Pune.
J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221077943. doi: 10.1177/23259582221077943.
: We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. : This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. : Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 cells/mm (SD: 284) respectively. A total of 382 (95%) PLHIV were virologically suppressed. The seropositivity against SARS-CoV-2 was found in 221 PLHIV (54.6%, 95% CI: 49.7-59.4). No significant association was found between demographic or clinical factors and seropositivity. : A high prevalence of anti-SARS-CoV-2 IgG antibodies was found among PLHIV attending ART centre indicating an exposure to the virus among them.
我们旨在确定印度浦那艾滋病毒感染者（PLHIV）中的抗严重急性呼吸系统综合征冠状病毒 2 型（SARS-CoV-2）IgG 抗体。这项横断面研究于 2021 年 3 月至 2021 年 6 月进行。记录了与 2019 年冠状病毒病（COVID-19）相关的人口统计学和临床信息。采集血样，使用商业 ELISA 检测抗 SARS-CoV-2 IgG 抗体。在研究中纳入的 405 名感染艾滋病毒的个体中，有 223 名（55.1%）为女性。参与者的平均年龄和 CD4 计数分别为 42 岁（标准差：10）和 626 个细胞/mm（标准差：284）。共有 382 名（95%）PLHIV 病毒学上得到抑制。在 221 名 PLHIV（54.6%，95%CI：49.7-59.4）中发现了针对 SARS-CoV-2 的血清阳性。在人口统计学或临床因素与血清阳性之间未发现显著关联。在接受抗逆转录病毒治疗（ART）中心就诊的 PLHIV 中发现了高比例的抗 SARS-CoV-2 IgG 抗体，这表明他们接触过该病毒。
