Department of Psychology, University of South Carolina, Columbia, South Carolina.
Pediatr Blood Cancer. 2022 Apr;69(4):e29590. doi: 10.1002/pbc.29590. Epub 2022 Feb 7.
Developmental monitoring and screening are recommended strategies for identifying children with sickle cell disease at high risk for cerebrovascular complications. Studies examining developmental screenings have provided little data on change over time. We examined screenings longitudinally in 43 children screened as two-year-olds and four-year-olds using the Ages and Stages Questionnaire, 2nd edition. Only two-thirds of children had stable screening outcomes. A new onset of cerebrovascular complications predicted the emergence of developmental delay (P = 0.017). Multivariate analysis suggested a benefit from formal developmental interventions. Regular developmental screening during the preschool period is important to identify systematic changes in developmental status.
发育监测和筛查是识别镰状细胞病患儿发生脑血管并发症风险较高的推荐策略。研究发育筛查的研究提供的随时间变化的数据很少。我们使用《年龄与阶段问卷》第 2 版对 43 名在 2 岁和 4 岁时接受筛查的儿童进行了纵向筛查。只有三分之二的儿童有稳定的筛查结果。新发脑血管并发症预示着发育迟缓的出现（P=0.017）。多变量分析表明，正式的发育干预有好处。在学前期间定期进行发育筛查对于识别发育状况的系统性变化很重要。
