Department of Endocrinology, 74639Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Department of Cardiac Center, 74639Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Angiology. 2022 May;73(5):470-477. doi: 10.1177/00033197211070884. Epub 2022 Feb 7.
The neutrophil to lymphocyte ratio (NLR) is a predictor of cardiovascular risk. However, little was known about the influence of sex in this relationship. The present study was designed to evaluate the association between NLR and coronary artery disease (CAD) risk and severity in males and females. A total of 810 patients (478 males and 332 females) who had undergone coronary angiography at the Beijing Chaoyang Hospital were enrolled. CAD severity was evaluated using the Gensini and SYNTAX scores. For males, the NLR was higher in CAD patients than that in non-CAD patients (all < .001). But there was no significant difference in NLR between female CAD and non-CAD patients ( = .222). The NLR correlated with the Gensini and SYNTAX scores in male CAD patients (both < .001), but this correlation was not found in female counterparts (both > .10). Logistic regression analyses and receiver operator characteristic curve (ROC) analyses showed that the NLR was an independent risk factor and a predictor of CAD in males (both < .01) but not in females (both > .10). In conclusion, the NLR was closely related to the presence and severity of CAD in males but not in females.
中性粒细胞与淋巴细胞比值（NLR）是心血管风险的预测因子。然而，关于性别在这种关系中的影响知之甚少。本研究旨在评估 NLR 与男性和女性冠状动脉疾病（CAD）风险和严重程度之间的关系。共纳入 810 例在北京朝阳医院接受冠状动脉造影的患者（男性 478 例，女性 332 例）。使用 Gensini 和 SYNTAX 评分评估 CAD 严重程度。对于男性，CAD 患者的 NLR 高于非 CAD 患者（均<0.001）。但是，女性 CAD 和非 CAD 患者的 NLR 之间没有显著差异（=0.222）。NLR 与男性 CAD 患者的 Gensini 和 SYNTAX 评分相关（均<0.001），但在女性患者中未发现这种相关性（均>0.10）。Logistic 回归分析和受试者工作特征曲线（ROC）分析表明，NLR 是男性 CAD 的独立危险因素和预测因子（均<0.01），但不是女性 CAD 的独立危险因素和预测因子（均>0.10）。总之，NLR 与男性 CAD 的存在和严重程度密切相关，但与女性 CAD 无关。
