Astrup A, Madsen J, Holst J J, Christensen N J
Metabolism. 1986 Mar;35(3):260-5. doi: 10.1016/0026-0495(86)90211-8.
Chronic ephedrine treatment of man has recently been found to enhance the thermogenic response to an acute dose of ephedrine. Conceivably, this sensitization to beta-adrenergic stimulation might also affect the facultative component of diet-induced thermogenesis. The glucose-induced thermogenesis (GIT) was studied in five healthy female subjects after 3 months of chronic peroral ephedrine treatment. Similar experiments 3 months after cessation of treatment served as controls. During chronic ephedrine treatment a sustained 10% elevation of the metabolic rate was found compared to that in the control study. Plasma epinephrine levels were increased 87% during treatment. These increases tended to be positively correlated (r = 0.54, P less than 0.07). GIT expressed as a percentage of the ingested energy load was unaltered during chronic ephedrine treatment compared with that in the control study (9.0% v 8.9%). The respiratory quotient (RQ) indicate that relatively more lipid was oxidized during chronic ephedrine treatment than in the control study. This change was observed in the fasting state as well as after glucose administration. Certain effects of ephedrine seems to be appropriate to a thermogenic drug for the treatment of obesity: A single dose of ephedrine stimulates thermogenesis, an effect that is enhanced during chronic treatment; Chronic treatment elevates the metabolic rate; and The substrate utilization is changed in favor of lipid oxidation.
最近发现，对人体进行慢性麻黄碱治疗可增强对急性剂量麻黄碱的产热反应。可以想象，这种对β-肾上腺素能刺激的致敏作用也可能影响饮食诱导产热的兼性成分。在5名健康女性受试者中，研究了经3个月慢性口服麻黄碱治疗后的葡萄糖诱导产热（GIT）。治疗停止3个月后进行的类似实验用作对照。在慢性麻黄碱治疗期间，发现代谢率持续比对照研究中升高10%。治疗期间血浆肾上腺素水平升高87%。这些升高呈现正相关趋势（r = 0.54，P < 0.07）。与对照研究相比，慢性麻黄碱治疗期间，以摄入能量负荷的百分比表示的GIT未发生改变（9.0%对8.9%）。呼吸商（RQ）表明，与对照研究相比，慢性麻黄碱治疗期间氧化的脂质相对更多。在禁食状态以及给予葡萄糖后均观察到这种变化。麻黄碱的某些作用似乎适合作为治疗肥胖症的产热药物：单剂量麻黄碱刺激产热，这种作用在慢性治疗期间增强；慢性治疗提高代谢率；底物利用发生变化，有利于脂质氧化。
